Hataminejad Maryam, Anvari Davood, Khaleghi Nahid, Nayeri Tooran, Shirazinia Reza, Shariatzadeh Seyyed Ali, Hosseini Seyed Abdollah, Siyadatpanah Abolghasem, Gholami Shirzad
Student Research Committee, Mazandaran University of Medical Science, Sari, Iran.
Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Vet Anim Sci. 2024 Mar 5;24:100345. doi: 10.1016/j.vas.2024.100345. eCollection 2024 Jun.
The larval stages of () are what cause the zoonotic disease known as alveolar echinococcosis (AE). Identifying the antigens that trigger immune responses during infection is extremely important for the development of vaccines against infections. Several studies conducted in recent decades have described the specific traits of the protective antigens found in and their role in immunizing different animal hosts. The objective of the current systematic review was to summarize the findings of relevant literature on this topic and unravel the most effective vaccine candidate antigens for future research. A comprehensive search was conducted across five databases, including ProQuest, PubMed, Scopus, ScienceDirect, and Web of Science, until March 1, 2023. Two reviewers autonomously conducted the screening and evaluation of data extraction and quality assessment. In the present study, a total of 41 papers matched the criteria for inclusion. The study findings indicate that the combination of Em14-3-3 and BCG is widely considered the most often employed antigens for immunization. In addition, the study describes antigen delivery, measurement of immune responses, adjuvants, animal models, as well as routes and doses of vaccination. The research indicated that recombinant vaccines containing EMY162, EM95, and EmII/3-Em14-3-3 antigens and crude or purified antigens containing ribotan-formulated excretory/secretory antigens exhibited the most favorable outcomes and elicited protective immune responses.
（某生物）的幼虫阶段会引发一种被称为肺泡型包虫病（AE）的人畜共患病。识别感染期间触发免疫反应的抗原对于开发针对（该生物）感染的疫苗极为重要。近几十年来进行的多项研究描述了在（该生物）中发现的保护性抗原的具体特征及其在免疫不同动物宿主中的作用。本系统综述的目的是总结关于该主题的相关文献的研究结果，并找出未来研究中最有效的候选疫苗抗原。截至2023年3月1日，在包括ProQuest、PubMed、Scopus、ScienceDirect和Web of Science在内的五个数据库中进行了全面搜索。两名评审员自主进行数据提取的筛选和评估以及质量评估。在本研究中，共有41篇论文符合纳入标准。研究结果表明，Em14 - 3 - 3和卡介苗（BCG）的组合被广泛认为是用于（该生物）免疫的最常用抗原。此外，该研究还描述了抗原递送、免疫反应的测量、佐剂、动物模型以及疫苗接种途径和剂量。研究表明，含有EMY162、EM95和EmII/3 - Em14 - 3 - 3抗原的重组疫苗以及含有核糖核酸配方排泄/分泌抗原的粗制或纯化抗原表现出最有利的结果，并引发了保护性免疫反应。
