Shimizu Takenori, Tanaka Shota, Kitagawa Yosuke, Sakaguchi Yusuke, Kamiya Mako, Takayanagi Shunsaku, Takami Hirokazu, Urano Yasuteru, Saito Nobuhito
Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Front Surg. 2024 Mar 7;11:1298709. doi: 10.3389/fsurg.2024.1298709. eCollection 2024.
Surgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary treatments with radical resection and chemoradiotherapy. Surgical resection of glioma is often complicated by the obscure border between the tumor and the adjacent brain tissues and by the tumor's infiltration into the eloquent brain. 5-aminolevulinic acid is frequently used for tumor visualization, as it exhibits high fluorescence in high-grade glioma. Here, we provide an overview of the fluorescent probes currently used for brain tumors, as well as those under development for other cancers, including HMRG-based probes, 2MeSiR-based probes, and other aminopeptidase probes. We describe our recently developed HMRG-based probes in brain tumors, such as PR-HMRG, combined with the existing diagnosis approach. These probes are remarkably effective for cancer cell recognition. Thus, they can be potentially integrated into surgical treatment for intraoperative detection of cancers.
大多数脑肿瘤都考虑进行手术切除，以获得组织诊断并根除肿瘤或减少肿瘤体积。胶质瘤是最常见的原发性恶性脑肿瘤，尽管采用了根治性切除和放化疗等多学科治疗方法，但其预后通常较差。胶质瘤的手术切除常常因肿瘤与相邻脑组织之间边界不清以及肿瘤浸润到功能区脑组织而变得复杂。5-氨基乙酰丙酸常用于肿瘤可视化，因为它在高级别胶质瘤中表现出高荧光。在此，我们概述了目前用于脑肿瘤的荧光探针，以及正在开发用于其他癌症的探针，包括基于HMRG的探针、基于2MeSiR的探针和其他氨肽酶探针。我们描述了我们最近在脑肿瘤中开发的基于HMRG的探针，如PR-HMRG，并结合现有的诊断方法。这些探针在癌细胞识别方面非常有效。因此，它们有可能被整合到手术治疗中，用于术中癌症检测。
