通过鼻内应用MTP-PE（一种亲脂性胞壁酰肽）诱导杀肿瘤白细胞。

Induction of tumouricidal leucocytes by the intranasal application of MTP-PE, a lipophilic muramyl peptide.

作者信息

Brownbill A F, Braun D G, Dukor P, Schumann G

出版信息

Cancer Immunol Immunother. 1985;20(1):11-7. doi: 10.1007/BF00199767.

DOI:10.1007/BF00199767

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038725/

Abstract

Single intranasal applications of MTP-PE, a lipophilic muramyl peptide, induce tumouricidal and tumouristatic leucocytes in the lungs of rats. In ex vivo assays the tumouristatic activity was detectable for 8 days after drug administration. By separation of the effector cells on Ficoll-Hypaque gradients, it was shown that both neutrophils and macrophages are responsible for this activity. Using the B16/BL6 melanoma system in mice, there was a high survival rate after repeated intranasal applications of MTP-PE.

摘要

亲脂性胞壁酰肽MTP - PE经鼻内单次给药可在大鼠肺中诱导产生具有杀肿瘤和抑肿瘤作用的白细胞。在体外试验中，给药后8天仍可检测到抑肿瘤活性。通过在Ficoll - Hypaque梯度上分离效应细胞，结果表明中性粒细胞和巨噬细胞均参与此活性作用。在小鼠的B16/BL6黑色素瘤模型中，经鼻内重复给予MTP - PE后小鼠存活率较高。

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Activation of tumoricidal properties in murine macrophages by intravenous injection of muramyl dipeptide encapsulated within liposomes as a treatment for spontaneous metastasis.

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In vitro activation of tumoricidal properties in rat alveolar macrophages by synthetic muramyl dipeptide encapsulated in liposomes.脂质体包裹的合成型胞壁酰二肽对大鼠肺泡巨噬细胞杀肿瘤特性的体外激活作用

Cell Immunol. 1981 Jan 1;57(1):42-50. doi: 10.1016/0008-8749(81)90118-0.

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Uptake of liposomes and liposome-encapsulated muramyl dipeptide by human peripheral blood monocytes.人外周血单核细胞对脂质体及脂质体包裹的胞壁酰二肽的摄取

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Human alveolar macrophages: potentiation of their tumoricidal activity by liposome-encapsulated muramyl dipeptide.人肺泡巨噬细胞：脂质体包裹的胞壁酰二肽增强其杀肿瘤活性。

J Immunol. 1982 Sep;129(3):1313-7.

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Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators.巨噬细胞在静脉注射含巨噬细胞激活剂的脂质体后对已形成转移灶的清除作用。

Cancer Res. 1982 Feb;42(2):496-501.

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Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide.脂质体结构和脂质组成对含胞壁酰二肽脂质体激活巨噬细胞杀肿瘤特性的影响。

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