通过鼻内应用MTP-PE（一种亲脂性胞壁酰肽）诱导杀肿瘤白细胞。
Induction of tumouricidal leucocytes by the intranasal application of MTP-PE, a lipophilic muramyl peptide.
作者信息
Brownbill A F, Braun D G, Dukor P, Schumann G
出版信息
Cancer Immunol Immunother. 1985;20(1):11-7. doi: 10.1007/BF00199767.
Abstract
Single intranasal applications of MTP-PE, a lipophilic muramyl peptide, induce tumouricidal and tumouristatic leucocytes in the lungs of rats. In ex vivo assays the tumouristatic activity was detectable for 8 days after drug administration. By separation of the effector cells on Ficoll-Hypaque gradients, it was shown that both neutrophils and macrophages are responsible for this activity. Using the B16/BL6 melanoma system in mice, there was a high survival rate after repeated intranasal applications of MTP-PE.
摘要
亲脂性胞壁酰肽MTP - PE经鼻内单次给药可在大鼠肺中诱导产生具有杀肿瘤和抑肿瘤作用的白细胞。在体外试验中，给药后8天仍可检测到抑肿瘤活性。通过在Ficoll - Hypaque梯度上分离效应细胞，结果表明中性粒细胞和巨噬细胞均参与此活性作用。在小鼠的B16/BL6黑色素瘤模型中，经鼻内重复给予MTP - PE后小鼠存活率较高。
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