Li Zheng-Ying, Cai Lu, Zhang Zhi-Jun, Zou Hai-Rong, He Mei, Qin Mei-Lin, Wang Hui
Department of Ultrasound, University-Town Hospital of Chongqing Medical University, No. 55 University Middle Road, Shapingba District, Chongqing, 401331, China.
Insights Imaging. 2024 Mar 22;15(1):85. doi: 10.1186/s13244-024-01646-3.
The endometrium of most unexplained infertility (UI) patients has been altered histologically. Shear wave elastography (SWE) is utilized to assess the signature of living tissue. This study aimed to explore the value of SWE in evaluating endometrial receptivity (ER) in UI patients.
In total, 59 UI patients (UI group) and 52 normal control women (NC group) who received fertility consultation in our hospital were included between January 2022 and June 2023. We divided them into the late-proliferative phase of UI group (LPUI; n = 59), mid-secretory phase of UI group (MPUI; n = 41), late-proliferative phase of NC group (LPNC; n = 52), and mid-secretory phase of NC group (MPNC; n = 45). Transvaginal ultrasonography and SWE were performed during the LP and MP. Endometrial thickness (EMT), uterine artery pulsatility index (UA-PI), endometrial mean elasticity (E-mean), and mean shear wave velocities (SWV-mean) were measured.
There were significant differences in E-mean, SWV-mean, EMT, and UA-PI between the UI group and the NC group during both the LP and MP (p < 0.05, p < 0.05). E-mean and SWV-mean decreased with increasing EMT but increased with increasing UA-PI (p < 0.05). The most effective parameter for evaluating ER in UI patients is the E-mean (AUC = 0.89).
UI patients exhibited thinner endometrium, increased endometrial stiffness, and poor endometrial blood perfusion. E-mean was the most effective parameter to evaluate ER in UI patients. The study preliminarily proved that SWE is a promising non-invasive tool for evaluating the condition of endometrium.
This study aimed to explore the significance of endometrial elasticity measured by SWE in evaluating patients with UI. The findings revealed a correlation between EMT, UA-PI, and E-mean. Endometrial elasticity can serve as an effective indicator for predicting ER.
大多数不明原因不孕症（UI）患者的子宫内膜存在组织学改变。剪切波弹性成像（SWE）用于评估活体组织特征。本研究旨在探讨SWE在评估UI患者子宫内膜容受性（ER）中的价值。
2022年1月至2023年6月，纳入我院接受生育咨询的59例UI患者（UI组）和52例正常对照女性（NC组）。将他们分为UI组的增殖晚期（LPUI；n = 59）、UI组的分泌中期（MPUI；n = 41）、NC组的增殖晚期（LPNC；n = 52）和NC组的分泌中期（MPNC；n = 45）。在增殖期（LP）和分泌期（MP）进行经阴道超声检查和SWE检查。测量子宫内膜厚度（EMT）、子宫动脉搏动指数（UA-PI）、子宫内膜平均弹性（E-mean）和平均剪切波速度（SWV-mean）。
在增殖期和分泌期，UI组与NC组之间的E-mean、SWV-mean、EMT和UA-PI均存在显著差异（p < 0.05，p < 0.05）。E-mean和SWV-mean随EMT增加而降低，但随UA-PI增加而升高（p < 0.05）。评估UI患者ER的最有效参数是E-mean（AUC = 0.89）。
UI患者子宫内膜较薄，子宫内膜硬度增加，子宫内膜血流灌注较差。E-mean是评估UI患者ER的最有效参数。本研究初步证明SWE是一种有前景的评估子宫内膜状况的非侵入性工具。
本研究旨在探讨SWE测量的子宫内膜弹性在评估UI患者中的意义。研究结果揭示了EMT、UA-PI和E-mean之间的相关性。子宫内膜弹性可作为预测ER的有效指标。
