Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Neurology Unit, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.
Neurol Sci. 2024 Aug;45(8):3599-3609. doi: 10.1007/s10072-024-07476-x. Epub 2024 Mar 22.
Although detailed diagnostic guidelines are available, differentiating dementia with Lewy bodies from Alzheimer's disease is often difficult. 123-I-MIBG cardiac scintigraphy is one of the tools which have been proposed for the diagnostic procedure. The present review is aimed at evaluating the available literature about this topic. Studies assessing the use of this technique to differentiate between the two diseases have been examined and reported. Overall, despite a certain study-to-study variability, the available literature suggests that 123-I-MIBG cardiac scintigraphy is an effective tool in differentiating between the two diseases, with high sensitivity and specificity values. Although the large-scale application of this technique is limited by possible interactions with specific medications and comorbidities, the reported studies are supportive for the usefulness of this technique in clinical practice.
尽管有详细的诊断指南，但将路易体痴呆与阿尔茨海默病区分开来通常很困难。123I-MIBG 心脏闪烁显像术是用于诊断程序的工具之一。本综述旨在评估该主题的现有文献。已检查并报告了评估该技术用于区分两种疾病的用途的研究。总体而言，尽管存在一定的研究间变异性，但现有文献表明，123I-MIBG 心脏闪烁显像术是区分这两种疾病的有效工具，具有较高的敏感性和特异性值。尽管该技术的大规模应用受到与特定药物和合并症的可能相互作用的限制，但报告的研究支持该技术在临床实践中的有用性。
