Center for Neurology, Academic Specialist Center, Stockholm, Sweden.
Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
J Parkinsons Dis. 2024;14(3):557-563. doi: 10.3233/JPD-230256.
Autonomic dysfunction is a prevalent feature of Parkinson's disease (PD), mediated by disease involvement of the autonomic nervous system. Chronotropic incompetence (CI) refers to inadequate increase of heart rate in response to elevated metabolic demand, partly dependent on postganglionic sympathetic tone. In a retrospective study, PD patients with/without CI were identified. We show that PD with CI was associated with a higher levodopa equivalent daily dose and Hoehn and Yahr stage, 5±2 years after motor onset. Our data support a putative role of CI as a clinical marker of a more severe disease phenotype, possibly reflecting more widespread alpha-synuclein pathology.
自主神经功能障碍是帕金森病（PD）的一个普遍特征，由自主神经系统的疾病累及介导。变时性功能不全（CI）是指心率对代谢需求增加的反应不足，部分依赖于节后交感神经张力。在一项回顾性研究中，确定了有/无 CI 的 PD 患者。我们表明，在运动发病后 5±2 年，CI 与较高的左旋多巴等效日剂量和 Hoehn 和 Yahr 分期相关。我们的数据支持 CI 作为更严重疾病表型的临床标志物的作用，可能反映了更广泛的α-突触核蛋白病理学。
