Department of Microbiology, Assam University Silchar, Silchar, Assam, India.
Department of Microbiology, Silchar Medical College, and Hospital, Silchar, Assam, India.
Indian J Med Microbiol. 2024 Mar-Apr;48:100563. doi: 10.1016/j.ijmmb.2024.100563. Epub 2024 Mar 23.
Therapeutic options for staphylococcus infections have been raised due to the emergence of VISA and VRSA. Six isolates of Staphylococcus aureus of clinical origin which were previously confirmed to carry vanG were selected for this study. Antimicrobial susceptibility was performed by disc diffusion method. Transcriptional expression of vanG and vanS showed down regulation against vancomycin and teicoplanin but expression was increased with increasing concentration of antibiotics. vanU, vanR showed up regulation against glycopeptide exposure. The present study underscored that expression of vanG and its regulatory gene operons are dependent on concentration of vancomycin and teicoplanin exposure in S.aureus.
由于耐万古霉素金黄色葡萄球菌（VISA）和耐万古霉素肠球菌（VRSA）的出现，治疗金黄色葡萄球菌感染的选择方案已经提高。本研究选择了 6 株临床来源的金黄色葡萄球菌分离株，这些分离株之前已被证实携带 vanG。通过圆盘扩散法进行了抗菌药物敏感性测试。vanG 和 vanS 的转录表达对万古霉素和替考拉宁表现出下调，但随着抗生素浓度的增加，表达增加。vanU、vanR 对糖肽暴露表现出上调。本研究强调，vanG 及其调控基因操纵子的表达取决于金黄色葡萄球菌中万古霉素和替考拉宁暴露的浓度。
