Bioresources Valorization Laboratory, Department of Chemical Engineering, Faculty of Engineering, University of Benin, Benin City, Edo State, Nigeria.
Bioresources Valorization Laboratory, Department of Chemical Engineering, Faculty of Engineering, University of Benin, Benin City, Edo State, Nigeria.
Environ Res. 2024 Jun 15;251(Pt 2):118703. doi: 10.1016/j.envres.2024.118703. Epub 2024 Mar 20.
Organic acids are important compounds with numerous applications in different industries. This work presents a comprehensive review of the biological synthesis of oxalic acid, an important organic acid with many industrial applications. Due to its important applications in pharmaceuticals, textiles, metal recovery, and chemical and metallurgical industries, the global demand for oxalic acid has increased. As a result, there is an increasing need to develop more environmentally friendly and economically attractive alternatives to chemical synthesis methods, which has led to an increased focus on microbial fermentation processes. This review discusses the specific strategies for microbial production of oxalic acid, focusing on the benefits of using bio-derived substrates to improve the economics of the process and promote a circular economy in comparison with chemical synthesis. This review provides a comprehensive analysis of the various fermentation methods, fermenting microorganisms, and the biochemistry of oxalic acid production. It also highlights key sustainability challenges and considerations related to oxalic acid biosynthesis, providing important direction for further research. By providing and critically analyzing the most recent information in the literature, this review serves as a comprehensive resource for understanding the biosynthesis of oxalic acid, addressing critical research gaps, and future advances in the field.
有机酸是一类具有广泛应用的重要化合物，在不同的工业领域都有应用。本工作全面综述了草酸的生物合成，草酸是一种具有许多工业应用的重要有机酸。由于其在制药、纺织、金属回收以及化学和冶金工业中的重要应用，全球对草酸的需求不断增加。因此，人们越来越需要开发出比化学合成方法更环保、更具经济吸引力的替代方法，这促使人们更加关注微生物发酵工艺。本综述讨论了微生物生产草酸的具体策略，重点介绍了使用生物衍生底物来提高工艺经济性并促进与化学合成相比的循环经济的好处。本综述全面分析了各种发酵方法、发酵微生物以及草酸生产的生物化学。它还强调了与草酸生物合成相关的关键可持续性挑战和考虑因素，为进一步的研究提供了重要的方向。通过提供和批判性地分析文献中的最新信息，本综述为理解草酸的生物合成提供了全面的资源，解决了关键的研究空白，并为该领域的未来进展提供了方向。
