Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Kidney Int. 2024 Apr;105(4):669-671. doi: 10.1016/j.kint.2024.01.009.
The 2022 Banff classification for kidney allograft pathology introduced the category "microvascular inflammation DSA-negative and C4d-negative" for cases without evidence of a humoral cause. Many questions remain about the etiology, prognosis, and treatment of this phenotype. Cristoferi et al. performed a molecular comparison of chronic active antibody-mediated rejection and its seronegative counterpart and suggest a central role for T cells in chronic donor-specific antibody-negative, C4d-negative microvascular inflammation. These results further question how we should classify rejection.
2022 年 Banff 肾脏移植病理学分类引入了“无体液病因证据的微血管炎症、DSA 阴性和 C4d 阴性”这一类别。对于这种表型，其病因、预后和治疗仍存在许多问题。Cristoferi 等人对慢性主动抗体介导的排斥反应及其血清阴性对应物进行了分子比较，提示 T 细胞在慢性供体特异性抗体阴性、C4d 阴性的微血管炎症中起核心作用。这些结果进一步质疑我们应该如何对排斥反应进行分类。
