Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg.
Semin Nucl Med. 2024 Sep;54(5):747-752. doi: 10.1053/j.semnuclmed.2024.02.006. Epub 2024 Mar 21.
PET probes targeting fibroblasts are frequently used for varying applications in oncology. In recent years, the clinical spectrum has been expanded towards cardiovascular medicine, e.g., after myocardial infarction, in aortic stenosis or as a non-invasive read-out of atherosclerosis. We herein provide a brief overview of the current status of this PET radiotracer in the context of cardiovascular disease, including translational and clinical evidence. In addition, we will also briefly discuss future applications, e.g., the use of fibroblast-targeting PET to investigate bilateral organ function along the cardiorenal axis.
用于各种肿瘤学应用的靶向成纤维细胞的 PET 探针。近年来，其临床应用范围已扩展至心血管医学，例如心肌梗死后、主动脉瓣狭窄时或作为动脉粥样硬化的非侵入性读出。在此，我们简要概述了该 PET 放射性示踪剂在心血管疾病方面的现状，包括转化和临床证据。此外，我们还将简要讨论未来的应用，例如使用靶向成纤维细胞的 PET 来研究沿心肾轴的双侧器官功能。
