Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Eastern Marine and Coastal Resources Research and Development Center, Rayong, Thailand.
J Vet Pharmacol Ther. 2024 Jul;47(4):300-307. doi: 10.1111/jvp.13441. Epub 2024 Mar 22.
The pharmacokinetics of florfenicol (FFC) in green sea and hawksbill sea turtles were evaluated following intramuscular (i.m.) administration at two different dosages of 20 or 30 mg/kg body weight (b.w.). This study (longitudinal design) used 5 green sea and 5 hawksbill sea turtles for the two dosages. Blood samples were collected at assigned times up to 168 h. FFC plasma samples were analyzed using validated high-performance liquid chromatography equipped with diode array detection. The pharmacokinetic analysis was performed using a non-compartment approach. The FFC plasma concentrations increased with the dosage. The elimination half-life was similar between the treatment groups (range 19-25 h), as well as the plasma protein binding (range 18.59%-20.65%). According to the surrogate PK/PD parameter (T > MIC, 2 μg/mL), the 20 and 30 mg/kg dosing rates should be effective doses for susceptible bacterial infections in green sea and hawksbill sea turtles.
氟苯尼考（FFC）在绿海龟和玳瑁体内的药代动力学，通过肌肉内（i.m.）注射两种不同剂量（20 或 30mg/kg 体重）进行评估。本研究（纵向设计）使用了 5 只绿海龟和 5 只玳瑁，每组剂量各 5 只。在 168 小时内，按规定时间采集血样。FFC 血浆样品采用经验证的高效液相色谱-二极管阵列检测法进行分析。药代动力学分析采用非房室模型方法进行。FFC 血浆浓度随剂量增加而增加。治疗组的消除半衰期相似（范围 19-25 小时），血浆蛋白结合率也相似（范围 18.59%-20.65%）。根据替代 PK/PD 参数（T > MIC，2μg/mL），20 和 30mg/kg 的给药剂量应能有效治疗绿海龟和玳瑁易感细菌感染。
