University of Health Science Hamidiye Sisli Etfal Education and Research Hospital, Otorhinolaryngology Department, Demokrasi Street, Huzur Neighbourhood, No:1, Sarıyer, İstanbul, Turkey.
University of Health Science Hamidiye Sisli Etfal Education and Research Hospital, Otorhinolaryngology Department, Demokrasi Street, Huzur Neighbourhood, No:1, Sarıyer, İstanbul, Turkey.
Auris Nasus Larynx. 2024 Jun;51(3):437-442. doi: 10.1016/j.anl.2023.12.003. Epub 2024 Mar 22.
OBJECTIVE(S): Our aim is to investigate the effects of the submucoperichondrial application of Platelet Rich Plasma (PRP) on nasal mucosal healing after septoplasty surgery.
METHOD(S): This prospective randomized observational study was conducted between July 2019 and February 2021, with 40 patients aged 18-60 years who underwent closed the only septoplasty operation for similar septal deviations. Patient divided into two group; 21 patients were placed in PRP group to which PRP was applied on all mucosal surface and submucoperichondrial area of septum and 19 patients were placed in control group to which saline solution was applied on same regions. Nasal obstruction score, mucociliary clearance time, presence of nasal crusting, and bleeding time were evaluated on 5th, 10th, 15th day after surgery and compared between groups.
Intranasal crusting on day 10 was found to be lower in the PRP group (n:13 68.4 %) than control group (n:7 33.3 %) with a statistically significant difference (p = 0.028). The nasal obstruction score on day 10 and 15 were found to be lower in the PRP group (3,33 ± 2,75, 2,07 ± 2,20) (than the control group (5,44 ± 2,26, 3,37 ± 1,92) with a statistically significant difference (p = 0,003,p = 0,009). The mucociliary clearance rate was found to be higher and the bleeding time was found to be lower in the PRP group, but a statistically significant difference was not observed.
Application of submucoperichondrial PRP could have beneficial effects on nasal mucosal repair, nasal crusting, and congestion after septoplasty surgery.
本研究旨在探讨富血小板血浆（PRP）在鼻中隔成形术后鼻腔黏膜愈合中的作用。
这是一项前瞻性随机观察研究，于 2019 年 7 月至 2021 年 2 月进行，共纳入 40 名年龄在 18-60 岁之间、接受单纯闭合性鼻中隔成形术治疗的患者。患者被分为两组：21 例患者被置于 PRP 组，PRP 被应用于鼻中隔的所有黏膜表面和黏膜下软骨膜区域；19 例患者被置于对照组，对照组在相同区域应用生理盐水。在术后第 5、10、15 天评估鼻腔阻塞评分、黏液纤毛清除时间、鼻腔结痂情况和出血时间，并对两组进行比较。
PRP 组第 10 天的鼻腔内结痂（n=13，68.4%）明显少于对照组（n=7，33.3%），差异具有统计学意义（p=0.028）。PRP 组第 10 天和第 15 天的鼻腔阻塞评分（3.33±2.75，2.07±2.20）明显低于对照组（5.44±2.26，3.37±1.92），差异具有统计学意义（p=0.003，p=0.009）。PRP 组的黏液纤毛清除率较高，出血时间较短，但差异无统计学意义。
鼻中隔成形术后应用黏膜下软骨膜 PRP 可能对鼻腔黏膜修复、结痂和充血有有益的影响。
