Department of Medicine and Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Italy.
Atherosclerosis. 2024 May;392:117523. doi: 10.1016/j.atherosclerosis.2024.117523. Epub 2024 Mar 16.
Altered metabolic function has many detrimental effects on the body that can manifest as cardiovascular and liver diseases. Traditional approaches to understanding and treating metabolic dysfunction-associated disorders have been organ-centered, leading to silo-type disease care. However, given the broad impact that systemic metabolic dysfunction has on the human body, approaches that simultaneously involve multiple medical specialists need to be developed and encouraged to optimize patient outcomes. In this review, we highlight how several of the treatments developed for cardiac care may have a beneficial effect on the liver and vice versa, suggesting that there is a need to target the disease process, rather than specifically target the cardiovascular or liver specific sequelae of metabolic dysfunction.
代谢功能的改变会对身体造成许多有害影响，表现为心血管疾病和肝脏疾病。传统的理解和治疗与代谢功能障碍相关疾病的方法是以器官为中心的，导致疾病护理的竖井式方法。然而，鉴于系统性代谢功能障碍对人体的广泛影响，需要开发和鼓励涉及多个医学专家的方法，以优化患者的治疗效果。在这篇综述中，我们强调了几种为心脏治疗开发的治疗方法可能对肝脏有有益的影响，反之亦然，这表明有必要针对疾病过程进行治疗，而不是专门针对代谢功能障碍的心血管或肝脏特定后果进行治疗。
