低血清抗缪勒管激素与参加随机对照试验筛选的不育男性的精液质量差有关。

Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial.

机构信息

Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.

Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.

出版信息

Fertil Steril. 2024 Aug;122(2):278-287. doi: 10.1016/j.fertnstert.2024.03.018. Epub 2024 Mar 24.

DOI:10.1016/j.fertnstert.2024.03.018

PMID:38522503

Abstract

OBJECTIVE

To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results.

DESIGN

Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial.

SETTING

Not applicable.

PATIENTS

At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration.

INTERVENTION

Not applicable.

MAIN OUTCOME MEASURES

Serum AMH concentration and semen quality.

RESULTS

All men were stratified according to serum AMH concentrations in quartiles (Q1-Q4). Men in the lowest quartile had a lower sperm concentration (1 × 10/mL) (Q1: 8.0 vs. Q2: 10.4 vs. Q3: 11.0 vs. Q4: 13.0), total sperm count (1 × 10) (Q1: 29.1 vs. Q2: 38.2 vs. Q3: 44.4 vs. Q4: 55.7), sperm motility (%) (Q1: 41 vs. Q2: 57 vs. Q3: 50 vs. Q4: 53), and progressive sperm motility (%) (Q1: 31 vs. Q2: 44 vs. Q3: 35 vs. Q4: 40) compared with the other quartiles. Moreover, men with a sperm concentration <2 million/mL had a lower serum AMH concentration compared with men having 2-16 × 10 /mL and >16 × 10/mL (31 pmol/L vs. 38 pmol/L vs. 43 pmol/L, respectively). In accordance, men with sperm motility <20% had a lower serum AMH concentration compared with men with sperm motility 20%-42%, and >42% (31 pmol/L vs. 43 pmol/L. vs. 39 pmol/L, respectively).

CONCLUSION

This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility.

CLINICAL TRIAL REGISTRATION NUMBER

NCT05212337.

摘要

目的

研究血清抗缪勒管激素（AMH）浓度与不育男性精液质量之间的可能关联。研究血清 AMH 浓度与不育男性精液质量之间关联的研究结果存在矛盾。

设计

在参加男性不育症治疗的首次研究的筛选期间，纳入不育男性进行研究，该研究为双盲、安慰剂对照、1:1、单中心随机对照试验。

地点

不适用。

患者

在筛选就诊时，400 名参与者提供了精液样本，并对其血清 AMH 浓度进行了分析。

干预

不适用。

主要观察指标

血清 AMH 浓度和精液质量。

结果

根据血清 AMH 浓度将所有男性分为四组（Q1-Q4）。血清 AMH 浓度最低的男性精子浓度（1×10/mL）较低（Q1：8.0 比 Q2：10.4 比 Q3：11.0 比 Q4：13.0），总精子数（1×10）（Q1：29.1 比 Q2：38.2 比 Q3：44.4 比 Q4：55.7），精子活力（%）（Q1：41 比 Q2：57 比 Q3：50 比 Q4：53），以及向前运动精子活力（%）（Q1：31 比 Q2：44 比 Q3：35 比 Q4：40）与其他四分位数相比。此外，精子浓度<200 万/mL 的男性血清 AMH 浓度低于精子浓度为 2-16×10 /mL 和>16×10/mL 的男性（31 pmol/L 比 38 pmol/L 比 43 pmol/L）。相应地，精子活力<20%的男性血清 AMH 浓度低于精子活力为 20%-42%和>42%的男性（31 pmol/L 比 43 pmol/L 比 39 pmol/L）。