School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales 2052, Australia; Maliba Pharmacy College, Uka Tarsadia University, Surat 394350, India.
Maliba Pharmacy College, Uka Tarsadia University, Surat 394350, India.
Cont Lens Anterior Eye. 2024 Jun;47(3):102154. doi: 10.1016/j.clae.2024.102154. Epub 2024 Mar 23.
Dry eye disease is a progressive prevalent ocular surface disorder that arises from various factors and is characterized by insufficient quality and/or quantity of tears. The underlying pathophysiology is intricate and can progress to chronic, difficult-to-treat conditions. Multiple strategies and therapeutic approaches are utilized in its management that target one or more etiopathological components of dry eyes, which may include aqueous tear deficiency or evaporative dry eyes. The primary focus of this paper is on treatment alternatives that utilize lipids for the treatment of evaporative dry eyes. This may arise from either abnormal lipid production or inadequate lipid spreading caused by meibomian gland dysfunction. The hypothesis behind the development of these lipid-containing eye drops is that if they can imitate the lipid layer, they may be able to help in the management of the signs and symptoms of evaporative dry eyes. The lipids used in commercial formulations for dry eyes are mineral oil, castor oil, phospholipids, omega-3 fatty acid, and medium-chain triglycerides. The literature suggests the potential of lipid-containing eye drops to alleviate some of the signs and symptoms and enhance the quality of life for individuals suffering from evaporative dry eyes.
干眼症是一种由多种因素引起的进行性常见眼表疾病，其特征是泪液质量和/或数量不足。其潜在的病理生理学机制复杂，可能进展为慢性、难以治疗的疾病。在其管理中采用了多种策略和治疗方法，针对干眼症的一个或多个病因病理成分，这些成分可能包括水样液缺乏或蒸发过强型干眼症。本文主要关注利用脂质治疗蒸发过强型干眼症的治疗选择。这可能是由于睑板腺功能障碍导致脂质产生异常或脂质分布不足。开发这些含脂滴眼液的假设是，如果它们能够模拟脂质层，它们可能有助于管理蒸发过强型干眼症的体征和症状。干眼症商业配方中使用的脂质包括矿物油、蓖麻油、磷脂、欧米伽-3 脂肪酸和中链甘油三酯。文献表明，含脂滴眼液有可能缓解一些体征和症状，并提高蒸发过强型干眼症患者的生活质量。
