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Clinical and molecular aspects of lead toxicity: An update.铅毒性的临床和分子方面:最新进展。
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2
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JAMA Pediatr. 2017 Jul 1;171(7):616-618. doi: 10.1001/jamapediatrics.2017.0775.
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Lead toxicity: a review.铅中毒:综述
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Lead toxicity.铅中毒
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Recommendations for blood lead screening of Medicaid-eligible children aged 1-5 years: an updated approach to targeting a group at high risk.医疗补助计划覆盖的1至5岁儿童血铅筛查建议:针对高危群体的最新方法。
MMWR Recomm Rep. 2009 Aug 7;58(RR-9):1-11.
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Neurotoxic effects and biomarkers of lead exposure: a review.铅暴露的神经毒性作用及生物标志物:综述
Rev Environ Health. 2009 Jan-Mar;24(1):15-45. doi: 10.1515/reveh.2009.24.1.15.
7
The lead industry and lead water pipes "A Modest Campaign".铅行业与铅质水管“一场适度的运动”
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8
Mechanisms of lead-induced hypertension and cardiovascular disease.铅诱导的高血压和心血管疾病的机制。
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9
Low-level environmental lead exposure and children's intellectual function: an international pooled analysis.低水平环境铅暴露与儿童智力功能:一项国际汇总分析。
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芝加哥的过去如何导致当下少数族裔儿童铅中毒比例过高:一项叙述性综述

How Chicago's Past Resulted in Disproportionate Lead Poisoning of Minority Children of the Present: A Narrative Review.

作者信息

Goodwin Glenn, Belok Todd, Bengio Moshe, Winners Bret, Fan Kevin, Garey Mitch, Scumpia Alexander J, Marra Erin M, Tortora Laura

机构信息

Emergency Medicine, Aventura Hospital and Medical Center, Miami, USA.

Emergency, University of Illinois at Chicago, Chicago, USA.

出版信息

Cureus. 2024 Mar 22;16(3):e56694. doi: 10.7759/cureus.56694. eCollection 2024 Mar.

DOI:10.7759/cureus.56694
PMID:38523874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10958577/
Abstract

Chicago's lead problem has been shown to disproportionately affect populations of color and lower socioeconomic status (SES). The disproportionate effects on low-income areas and communities of color can be traced back to several key decisions in Chicago's history. A search of the National Library of Medicine's MEDLINE/PubMed as well as Google, and Google Scholar was performed to find all articles relating to lead poisoning in Chicago, lead utilization, Chicago's municipal and political history, and lead physiology between May 2020 and May 2023. Additionally, several studies and textbooks were reviewed regarding the latest advancements in lead poisoning. The study identified several key political moves over the course of Chicago's history that have resulted in disproportionate toxicity in minority populations and those of lower SES. Lead is more readily absorbed in the pediatric population. Additionally, prior regulations had published acceptable blood lead levels (BLLs) in children, but more recent evidence indicates a myriad of detrimental effects in BLLs below that cutoff. There is substantial evidence to suggest that there is no acceptable BLL. Lead toxicity is generally improving nationally but there still exists a considerable need for improvement. Programs should be expanded to ensure that individuals living in communities most at risk of lead exposure have the means to both, replace lead-contaminated infrastructure, and to be able to supply these communities with affordable housing. From a physician and clinician standpoint, knowing the increased risk of lead poisoning in these populations should prompt earlier testing.

摘要

芝加哥的铅污染问题已被证明对有色人种群体和社会经济地位较低(SES)的人群影响尤为严重。对低收入地区和有色人种社区的这种不均衡影响可以追溯到芝加哥历史上的几个关键决策。我们检索了美国国立医学图书馆的MEDLINE/PubMed以及谷歌和谷歌学术,以查找2020年5月至2023年5月期间所有与芝加哥铅中毒、铅的使用、芝加哥的市政和政治历史以及铅生理学相关的文章。此外,还查阅了几项关于铅中毒最新进展的研究和教科书。该研究确定了芝加哥历史进程中的几个关键政治举措,这些举措导致少数族裔和社会经济地位较低的人群中毒情况更为严重。铅在儿童群体中更容易被吸收。此外,先前的法规公布了儿童可接受的血铅水平(BLLs),但最近的证据表明,低于该临界值的血铅水平也会产生一系列有害影响。有大量证据表明不存在可接受的血铅水平。全国范围内铅中毒情况总体上正在改善,但仍有很大的改进空间。应扩大相关项目,以确保生活在铅暴露风险最高社区的个人有办法更换受铅污染的基础设施,并能够为这些社区提供经济适用房。从医生和临床医生的角度来看,了解这些人群中铅中毒风险增加应促使更早进行检测。