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超显微外科淋巴管静脉吻合术治疗继发性淋巴水肿后对专利蓝染料的过敏反应

Anaphylactic Reaction to Patent Blue Dye After Supermicrosurgical Lymphaticovenular Anastomosis for the Treatment of Secondary Lymphedema.

作者信息

Heymans Sina, Sleutel Arie, Schoeller Thomas, Weitgasser Laurenz

机构信息

Department of Plastic and Reconstructive Surgery, Marienhospital Stuttgart, Stuttgart, DEU.

出版信息

Cureus. 2024 Feb 23;16(2):e54767. doi: 10.7759/cureus.54767. eCollection 2024 Feb.

DOI:10.7759/cureus.54767
PMID:38523994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10961146/
Abstract

For decades, patent blue dye (PBV) has been utilized for sentinel lymph node biopsy and lymphatic mapping in breast cancer and melanoma staging and treatment. Fistulography and intraoperative display of lymphatic vessels for lymphaticovenular anastomosis (LVA) are frequent applications. Although its anaphylactic potential is well described, PBV is used routinely. We present the case of a 71-year-old female patient, who underwent LVA for the treatment of chronic secondary lymphedema and experienced a postoperative anaphylactic reaction including a blue-colored drug-induced maculopapular exanthema after PBV administration. This article aims to raise awareness of potential life-threatening allergic reactions and propose an alternative to PBV.

摘要

几十年来，专利蓝染料（PBV）一直用于乳腺癌和黑色素瘤分期及治疗中的前哨淋巴结活检和淋巴管造影。瘘管造影以及用于淋巴静脉吻合术（LVA）的淋巴管术中显示是其常见应用。尽管PBV的过敏潜力已得到充分描述，但仍被常规使用。我们报告了一例71岁女性患者的病例，该患者接受LVA治疗慢性继发性淋巴水肿，在注射PBV后出现术后过敏反应，包括药物性蓝色斑丘疹。本文旨在提高对潜在危及生命的过敏反应的认识，并提出PBV的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/10961146/79c9f664ee60/cureus-0016-00000054767-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/10961146/79c9f664ee60/cureus-0016-00000054767-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba03/10961146/79c9f664ee60/cureus-0016-00000054767-i01.jpg

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Anaphylactic Reaction to Patent Blue Dye After Supermicrosurgical Lymphaticovenular Anastomosis for the Treatment of Secondary Lymphedema.超显微外科淋巴管静脉吻合术治疗继发性淋巴水肿后对专利蓝染料的过敏反应
Cureus. 2024 Feb 23;16(2):e54767. doi: 10.7759/cureus.54767. eCollection 2024 Feb.
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本文引用的文献

1
A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision.一例前哨淋巴结切除患者对专利蓝过敏的病例
Iran J Allergy Asthma Immunol. 2016 Dec;15(6):547-550.
2
Adverse drug reaction, patent blue V dye and anaesthesia.药物不良反应、专利蓝V染料与麻醉
Indian J Anaesth. 2012 Nov;56(6):563-6. doi: 10.4103/0019-5049.104576.
3
Patent blue-enhanced lymphaticovenular anastomosis.专利蓝色增强淋巴管-静脉吻合术。
J Plast Reconstr Aesthet Surg. 2013 Mar;66(3):382-9. doi: 10.1016/j.bjps.2012.10.019. Epub 2012 Dec 4.
4
Investigation of anaphylactic reaction after patent blue V dye injection.专利蓝 V 染料注射后过敏反应的调查。
Breast. 2010 Dec;19(6):516-20. doi: 10.1016/j.breast.2010.05.016. Epub 2010 Jun 23.
5
Anaphylaxis to Patent Blue V. I. Clinical aspects.专利蓝 V 引起的过敏反应。I. 临床方面。
Allergy. 2010 Jan;65(1):117-23. doi: 10.1111/j.1398-9995.2009.02192.x. Epub 2009 Sep 30.
6
Patent blue dye in lymphaticovenular anastomosis.淋巴管静脉吻合术中的专利蓝染料。
Ann Acad Med Singap. 2009 Aug;38(8):704-6.
7
A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph node biopsy for breast cancer.异硫蓝与亚甲蓝染料在乳腺癌前哨淋巴结活检中相关不良反应的比较。
Am J Surg. 2005 Feb;189(2):236-9. doi: 10.1016/j.amjsurg.2004.06.042.
8
Allergic reactions: following patent blue dye injection.过敏反应：注射专利蓝染料后。
Can Med Assoc J. 1969 Nov 15;101(10):100-1.