Kemps Glen J F, de Boer Douwe, Tijssen Maud P M, Kunst Dirk H P M, Waterval Jérôme J
Department of Otolaryngology, Isala Hospital, Zwolle, the Netherlands.
Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, the Netherlands.
Heliyon. 2024 Mar 16;10(6):e28059. doi: 10.1016/j.heliyon.2024.e28059. eCollection 2024 Mar 30.
Cerebrospinal fluid (CSF) fistulas are a rare phenomenon, that can lead to life-threatening complications if left untreated. Presenting as rhinorrhea or otorrhea, they can be difficult to diagnose due to admixture of other bodily fluids. Typically, CSF fistulas develop after trauma, but in rare instances, they can be diagnosed in patients with a neoplastic lesion.
To discuss several steps in diagnosing CSF fistulas.
A fifty-year-old female with an intra-osseous temporal bone meningioma.
For diagnosing CSF admixture in fluids, two tests are looked into: beta-2 transferrin (β2T) and beta-trace protein (βTP) testing.
Testing for βTP is a highly sensitive, quick and non-invasive method to assess CSF admixture in middle ear effusion. Because of its lower cost, faster results and easy sample collection, βTP testing has in our clinic replaced β2T testing. The current case illustrates a rare etiology of a CSF fistula, where β2T testing presumably showed false-negative results and βTP testing showed true-positive results.
脑脊液瘘是一种罕见现象，如果不治疗可能导致危及生命的并发症。表现为鼻漏或耳漏，由于与其他体液混合，可能难以诊断。通常，脑脊液瘘在创伤后发生，但在罕见情况下，可在患有肿瘤性病变的患者中诊断出来。
讨论诊断脑脊液瘘的几个步骤。
一名50岁患有颞骨内脑膜瘤的女性。
为诊断液体中的脑脊液混合情况，研究了两种检测方法：β2转铁蛋白（β2T）检测和β-微量蛋白（βTP）检测。
βTP检测是评估中耳积液中脑脊液混合情况的一种高度敏感、快速且非侵入性的方法。由于其成本较低、结果更快且样本采集容易，βTP检测在我们诊所已取代β2T检测。本病例说明了脑脊液瘘的一种罕见病因，其中β2T检测可能显示假阴性结果，而βTP检测显示真阳性结果。
