Association of and polymorphisms in COVID-19 host severity and non-survival.

BACKGROUND

Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown.

METHODOLOGY

We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for (rs1005753 and rs2235926) and (rs11203366, rs11203367, and rs874881) SNPs by TaqMan assays and their associations with disease severity, death, and inflammatory biomarkers were evaluated.

RESULTS

291 patients presented had severe COVID-19 according to PaO/FiO, and 393 had a non-survival outcome. Carriers of the rs1005753 G/G genotype in the gene presented susceptibility for severe COVID-19, while the heterozygous carriers in rs11203366, rs11203367, and rs874881 of the gene showed risk of death. The GTACC haplotype in - was associated with susceptibility to severe COVID-19, while the GCACC haplotype was a protective factor. The GCGTG haplotype was associated with severe COVID-19 but as a protective haplotype for death. Finally, the GTACC haplotype was associated with platelet-to-lymphocyte ratio (PLR), the GCACC haplotype with neutrophil-to-hemoglobin and lymphocyte and the GCGTG haplotype as a protective factor for the elevation of procalcitonin, D-dimer, CRP, LCRP, NHL, SII, NLR, and PLR.

CONCLUSIONS

Our results suggest that the haplotypic combination of GTACC and some individual genotypes of and contribute to the subjects' susceptibility for severity and death by COVID-19.