Ashindoitiang John Adi, Nwagbara Victor Ikechukwu Canice, Ipeh Theophilus Ugbem, Chukwu Ben, Obanife Henry Olaleye, Eyong Alfred Ottoh, Asuquo Maurice Efana
Department of Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar.
Department of Pathology, University of Calabar/University of Calabar Teaching Hospital, Calabar.
Rare Tumors. 2024 Mar 21;16:20363613241242383. doi: 10.1177/20363613241242383. eCollection 2024.
The existence of both neuroendocrine and non-neuroendocrine histology in variable proportion in a lesion has been described by the World Health Organisation (WHO) as mixed neuroendocrine and non-neuroendocrine neoplasm (MiNEN). The pathogenesis of this tumour remains controversial but molecular studies point towards a common monoclonal origin. Tumours are classified as functioning and nonfunctioning based on substances secreted. The nonfunctioning tumours may be discovered due to its local effect. Presented is a 66-year-old male with an intra-abdominal mass, underwent laparotomy and excision biopsy with transient right lower limb lymphoedema. Histology confirmed retroperitoneal MiNEN with no evidence of tumour recurrence 12 months following surgery. MiNENs should be considered as a differential diagnosis in patients with intra-abdominal mass. Surgical resection is recommended as this may offer the best treatment option.
世界卫生组织（WHO）将病变中以不同比例同时存在神经内分泌和非神经内分泌组织学的情况描述为混合性神经内分泌和非神经内分泌肿瘤（MiNEN）。该肿瘤的发病机制仍存在争议，但分子研究表明其起源于共同的单克隆。肿瘤根据分泌的物质分为功能性和非功能性。非功能性肿瘤可能因其局部效应而被发现。本文介绍了一名66岁男性，其腹部有肿物，接受了剖腹手术和切除活检，术后出现短暂性右下肢淋巴水肿。组织学证实为腹膜后MiNEN，术后12个月无肿瘤复发迹象。对于有腹部肿物的患者，应将MiNEN视为鉴别诊断之一。建议进行手术切除，因为这可能是最佳的治疗选择。
