Celidonio Joseph, Bahethi Rohini, Malhotra Raj, Yan Kenneth
Department of Otolaryngology - Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA.
Laryngoscope Investig Otolaryngol. 2024 Mar 23;9(2):e1231. doi: 10.1002/lio2.1231. eCollection 2024 Apr.
Hematologic malignancy involving the trachea is rare. It is even less common for tracheal involvement to be the initial manifestation of this disease. We present a case report highlighting an unusual diagnosis of acute myeloid leukemia (AML) that first presented with prominent tracheal manifestations. There have been only three other published case reports of extramedullary AML with involvement of the trachea.
We discuss direct laryngoscopy and bronchoscopy findings, including pinkish-white irregular lesions, which were similar to findings described in the available literature for tracheal AML.
Laboratory findings from our case are reported, including peripheral smear demonstrating 57% blasts and bone marrow biopsy confirming the diagnosis of AML, and the relevance of these findings is discussed.
In patients with unusual airway lesions, laboratory testing and a comprehensive airway evaluation including biopsy are necessary to narrow the differential diagnosis.
累及气管的血液系统恶性肿瘤较为罕见。气管受累作为该疾病的首发表现则更为少见。我们报告一例病例，突出了以显著气管表现为首发症状的急性髓系白血病（AML）这一不寻常的诊断。此前仅有另外三篇关于气管受累的髓外AML的病例报告发表。
我们讨论了直接喉镜和支气管镜检查结果，包括粉白色不规则病变，这与现有文献中描述的气管AML的表现相似。
报告了我们病例的实验室检查结果，包括外周血涂片显示57%的原始细胞以及骨髓活检确诊为AML，并讨论了这些结果的相关性。
对于有不寻常气道病变的患者，进行实验室检查以及包括活检在内的全面气道评估对于缩小鉴别诊断范围是必要的。
5级。
