Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Expert Rev Mol Med. 2024 Mar 25;26:e3. doi: 10.1017/erm.2024.2.
Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.
去泛素化酶是一组能够识别和分解连接在底物蛋白上的单泛素链或多泛素链的蛋白质，防止底物蛋白被泛素蛋白酶体系统降解。去泛素化酶通过作用于不同的底物蛋白来调节细胞自噬、代谢和氧化应激。最近的研究表明，去泛素化酶在各种心脏疾病中作为关键调节剂发挥作用，并通过广泛的机制控制心脏疾病的发生和进展。本综述总结了不同去泛素化酶在心脏疾病中的作用，包括心脏肥大、心肌梗死和糖尿病相关的心脏疾病。此外，本综述简要回顾了去泛素化酶调节剂在心脏疾病中的作用，为未来提供了潜在的治疗靶点。
