School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, P. R. China.
J Mater Chem B. 2024 Apr 3;12(14):3521-3532. doi: 10.1039/d3tb02822d.
The combination of photothermal therapy and chemotherapy has emerged as a promising strategy to improve cancer therapeutic efficacy. However, developing a versatile nanoplatform that simultaneously possesses commendable photothermal effect and high drug encapsulation efficiency remains a challenging problem yet to be addressed. Herein, we report a facile supramolecular self-assembly strategy to construct gold nanoparticle clusters (AuNCs) for synergistic photothermal-chemo therapy. By utilizing the functional polysaccharide as a targeted ligand, hyaluronic acid-enriched AuNCs were endowed with targeting CD44 receptor overexpressed on the B16 cancer cells. Importantly, these hyaluronic acid modified AuNCs can shelter therapeutic cargo of doxorubicin (DOX) to aggregate larger nanoparticles a host-guest interaction with the anchored β-cyclodextrin, as a "nanocluster-bomb" (DOX@AuNCs). The results revealed that these DOX@AuNCs showed light-triggered drug release behavior and synergistic photothermal-chemo therapy. The improved efficacy of synergistic therapy was further demonstrated by treating a xenografted B16 tumor model . We envision that our multipronged design of DOX@AuNCs provides a potent theranostic platform for precise cancer therapy and could be further enriched by introducing different imaging probes and therapeutic drugs as appropriate suitable guest molecules.
光热治疗和化学疗法的联合已成为提高癌症治疗效果的一种有前途的策略。然而，开发同时具有卓越的光热效应和高药物包封效率的多功能纳米平台仍然是一个尚未解决的挑战。在此，我们报告了一种简便的超分子自组装策略，用于构建用于协同光热-化疗的金纳米颗粒簇（AuNCs）。通过利用功能性多糖作为靶向配体，使富含透明质酸的 AuNCs 具有针对 B16 癌细胞过度表达的 CD44 受体的靶向性。重要的是，这些透明质酸修饰的 AuNCs 可以屏蔽多柔比星（DOX）等治疗药物货物，通过与锚定的β-环糊精的主客体相互作用聚集更大的纳米颗粒，形成“纳米簇炸弹”（DOX@AuNCs）。结果表明，这些 DOX@AuNCs 表现出光触发的药物释放行为和协同光热-化疗。通过治疗异种移植的 B16 肿瘤模型进一步证明了协同治疗的疗效提高。我们设想，我们设计的 DOX@AuNCs 的多管齐下为精确癌症治疗提供了一个强大的治疗平台，并可以通过适当引入不同的成像探针和治疗药物作为合适的客体分子进一步丰富。
