Meeroff J C, Rubinstein M, Luis A, Waciarz M, Eguia O, Meeroff M
Dig Dis Sci. 1979 Sep;24(9):680-3. doi: 10.1007/BF01314464.
A double-blind 4-week trial of sodium oxyferriscorbone versus placebo (distilled water) was conducted in 46 outpatients with endoscopically confirmed gastric ulcer. Ulcer healing occurred in 15 of 20 patients receiving sodium oxyferriscorbone (75%) and in 7 of 20 patients receiving placebo (35%). Patients receiving sodium oxyferriscorbone experienced less pain and required less antacid than those receiving placebo (P less than 0.05). Side effects were reported in 12 patients, 7 while receiving sodium oxyferriscorbone and 5 while receiving placebo. Six patients did not complete the study due to ulcer complications. Routine laboratory tests revealed no persistent abnormalities that could be related to the treatment. Five placebo-treated patients that were therapeutic failures were switched to sodium oxyferriscorbone and healing was observed within 3 weeks. It is concluded that sodium oxyferriscorbone is effective in enhancing healing of gastric ulcers.
对46例经内镜确诊为胃溃疡的门诊患者进行了一项为期4周的双盲试验，比较氧铁骨化钠与安慰剂（蒸馏水）的疗效。20例接受氧铁骨化钠治疗的患者中有15例溃疡愈合（75%），20例接受安慰剂治疗的患者中有7例溃疡愈合（35%）。与接受安慰剂的患者相比，接受氧铁骨化钠治疗的患者疼痛较轻，所需抗酸剂较少（P<0.05）。12例患者报告有副作用，7例在接受氧铁骨化钠治疗时出现，5例在接受安慰剂治疗时出现。6例患者因溃疡并发症未完成研究。常规实验室检查未发现与治疗相关的持续性异常。5例接受安慰剂治疗失败的患者改用氧铁骨化钠治疗，3周内观察到溃疡愈合。结论是氧铁骨化钠在促进胃溃疡愈合方面有效。
