Department of Food Science and Nutrition, Pukyong National University, Busan, Korea.
Biotechnology Research Division, National Institute of Fisheries Science, Busan, Republic of Korea.
J Med Food. 2024 Apr;27(4):359-368. doi: 10.1089/jmf.2023.K.0160. Epub 2024 Mar 22.
As the body's largest organ, the skin is located at the internal and external environment interface, serving as a line of defense against various harmful stressors. Recently, marine-derived physiologically active ingredients have attracted considerable attention in the cosmeceutical industry due to their beneficial effects on skin health. , a genus of brown macroalgae, has traditionally been consumed as food and medicine in several countries and is rich in bioactive compounds such as meroterpenoids, sulfated polysaccharides, fucoidan, fucoxanthin, flavonoids, and terpenoids. spp. have various beneficial effects on skin disorders. They help with atopic dermatitis by improving skin barrier protection and reducing inflammation. Several species show potential in treating acne by inhibiting bacterial growth and reducing inflammation. Some species, such as , demonstrate antiallergic effects by modulating mast cell activity. Certain species exhibit anticancer activity by inhibiting tumor growth and promoting apoptosis, and some species help with wound healing by promoting angiogenesis and reducing oxidative stress. Overall, spp. demonstrate potential for treating and managing various skin conditions. Therefore, the bioactive compounds of spp. may be natural ingredients with a wide range of functional properties for preventing and treating skin disorders. The present review focused on the various biological effects of extracts and derived compounds on skin disorders.
皮肤是人体最大的器官，位于内外部环境界面，是抵御各种有害应激源的第一道防线。最近，海洋来源的具有生理活性的成分因其对皮肤健康的有益作用而在化妆品行业引起了相当大的关注。褐藻属是一种褐藻，在几个国家传统上被用作食物和药物，并且富含生物活性化合物，如倍半萜、硫酸多糖、褐藻聚糖、岩藻黄质、类黄酮和萜类化合物。褐藻属对皮肤疾病有各种有益的作用。它们通过改善皮肤屏障保护和减少炎症来帮助治疗特应性皮炎。一些物种通过抑制细菌生长和减少炎症显示出在治疗痤疮方面的潜力。某些物种，如，通过调节肥大细胞活性显示出抗过敏作用。某些褐藻属物种通过抑制肿瘤生长和促进细胞凋亡来表现出抗癌活性，某些物种通过促进血管生成和减少氧化应激来帮助伤口愈合。总的来说，褐藻属对各种皮肤状况有治疗和管理的潜力。因此，褐藻属的生物活性化合物可能是具有广泛功能特性的天然成分，可用于预防和治疗皮肤疾病。本综述重点介绍了褐藻属提取物和衍生化合物对皮肤疾病的各种生物学作用。
