Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Mater Sci Mater Med. 2024 Mar 25;35(1):21. doi: 10.1007/s10856-024-06786-y.
The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8 T cells and NKp46 NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors.
电纺载药纳米复合材料抑制膀胱癌生长及转移的实验研究
电纺载药纳米复合材料的制备及体内外研究
当前研究通过电纺技术制备载有吉西他滨（GEM）和顺铂（CDDP）的纳米复合材料。体外和体内研究均表明，该纳米复合材料能够有效抑制肿瘤进展，同时减少化疗药物在肝、肾组织中的蓄积。从机制上看，电纺载药纳米复合材料可有效消除肿瘤组织中的髓源抑制细胞（MDSCs），募集 CD8+T 细胞和 NKp46+NK 细胞杀伤肿瘤细胞，还能有效抑制肿瘤微血管形成。本研究通过局部给予载有 GEM 和 CDDP 的电纺纳米复合材料来干预肿瘤微环境，为肿瘤治疗提供了新的思路。
