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《中国髓外浆细胞瘤诊断与治疗专家共识(2024年版)》

[Consensus for the diagnosis and management of extramedullary plasmacytoma in China(2024)].

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2024 Jan 14;45(1):8-17. doi: 10.3760/cma.j.cn121090-20231107-00253.

DOI:10.3760/cma.j.cn121090-20231107-00253
PMID:38527832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10951115/
Abstract

Extramedullary plasmacytoma (EMP) is a special type of malignant plasmacytosis, which is complex and heterogeneous. Most EMP patients have poor prognosis and lack a stratified prognostic system or ideal treatment strategy supported by evidence-based medical evidence, which cannot meet clinical needs. In order to improve the understanding of this disease entity, Plasma Cell Disease Group, Chinese Society of Hematology, Chinese Medical Association and Chinese Myeloma Committee-Chinese Hematology Association developed the "Chinese Expert Consensus on the diagnosis and treatment of extramedullary plasmacytoma", which aims to standardize the clinical diagnosis and treatment of EMP and ultimately improve the overall survival of patients with plasmacytoma.

摘要

髓外浆细胞瘤(EMP)是一种特殊类型的恶性浆细胞增多症,其具有复杂性和异质性。大多数EMP患者预后较差,缺乏分层的预后系统或循证医学证据支持的理想治疗策略,无法满足临床需求。为提高对这一疾病实体的认识,中华医学会血液学分会浆细胞疾病学组、中国骨髓瘤委员会-中华血液学会制定了《髓外浆细胞瘤诊断与治疗中国专家共识》,旨在规范EMP的临床诊断与治疗,最终提高浆细胞瘤患者的总生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec6a/10951115/aa998ba59cbf/cjh-45-01-008-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec6a/10951115/e4cc4a4c948f/cjh-45-01-008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec6a/10951115/aa998ba59cbf/cjh-45-01-008-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec6a/10951115/e4cc4a4c948f/cjh-45-01-008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec6a/10951115/aa998ba59cbf/cjh-45-01-008-g002.jpg

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Efficacy of Bendamustine, Pomalidomide, and Dexamethasone (BPD) Regimen in Relapsed/Refractory Extramedullary Myeloma: A Retrospective Single-Centre Study, Real-Life Experience.苯达莫司汀、泊马度胺和地塞米松(BPD)方案治疗复发/难治性髓外骨髓瘤的疗效:一项回顾性单中心研究及真实世界经验
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Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing.通过单细胞 RNA 测序鉴定骨髓瘤性渗出液的进化机制。
Blood Adv. 2023 Aug 8;7(15):4148-4159. doi: 10.1182/bloodadvances.2022009477.
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Five-year remission without disease progression in a patient with relapsed/refractory multiple myeloma with extramedullary disease treated with LCAR-B38M chimeric antigen receptor T cells in the LEGEND-2 study: a case report.在 LEGEND-2 研究中,接受 LCAR-B38M 嵌合抗原受体 T 细胞治疗的复发/难治性多发性骨髓瘤伴髓外疾病患者获得 5 年无疾病进展缓解:一例报告。
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Phase II trial of daratumumab with DCEP in relapsed/refractory multiple myeloma patients with extramedullary disease.DCEP 联合达雷妥尤单抗治疗伴有髓外疾病的复发/难治性多发性骨髓瘤患者的 II 期临床试验。
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