Ayele Akeberegn Gorems, Kawet Jeylan Sinba
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
J Exp Pharmacol. 2024 Mar 21;16:135-142. doi: 10.2147/JEP.S456029. eCollection 2024.
People frequently complain of long-term constipation. The cost associated with using modern medications to treat constipation is significant, and the probability of encountering side effects is notably high. These limitations restrict their effectiveness in therapy, remain unresolved, and underscore the need for research on alternative therapeutic approaches. Plants of the genus have been used to treat constipation. Therefore, the aim of this study was to evaluate the laxative effects of aqueous leaf and stem extracts of in mice.
The laxative activity of A. leaf and stem extracts was evaluated using three models: laxative activity, gastrointestinal motility, and gastrointestinal secretion. In this study, bisacodyl was used as a standard laxative and loperamide was used to induce constipation.
In the laxative test, 200 (P<0.05) and 400 mg/kg (p<0.01) doses of plant extract significantly increased the percentage of fecal water content. Moreover, the highest dose of extract increased the frequency of defecation after 12 h (p<0.05). In the remaining two models, the experimental plans also showed significantly higher gastrointestinal motility and noticeable accumulation of intestinal fluid.
The results of this study indicate that aqueous leaf and stem extracts of have laxative effects.
人们经常抱怨长期便秘。使用现代药物治疗便秘的成本很高，而且出现副作用的可能性也非常高。这些局限性限制了它们在治疗中的有效性，仍然没有得到解决，这突出了对替代治疗方法进行研究的必要性。[该属植物]已被用于治疗便秘。因此，本研究的目的是评估[该植物]叶和茎水提取物对小鼠的通便作用。
使用三种模型评估[该植物]叶和茎提取物的通便活性：通便活性、胃肠动力和胃肠分泌。在本研究中，比沙可啶用作标准泻药，洛哌丁胺用于诱导便秘。
在通便试验中，200（P<0.05）和400mg/kg（p<0.01）剂量的植物提取物显著增加了粪便含水量的百分比。此外，最高剂量的提取物在12小时后增加了排便频率（p<0.05）。在其余两个模型中，实验方案也显示出显著更高的胃肠动力和明显的肠液积聚。
本研究结果表明，[该植物]叶和茎的水提取物具有通便作用。
