Ji Wenqing, Wan Tiantian, Zhang Fang, Guo Shubin, Mei Xue
Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Infect Drug Resist. 2024 Mar 21;17:1153-1160. doi: 10.2147/IDR.S447922. eCollection 2024.
Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a crucial angiogenic factor that is involved in a variety of diseases and in the regulation of inflammatory responses. However, its role in sepsis is poorly understood. We have investigated the role of AGGF1 in the classification and prognostic evaluation of adult septic patients in a clinical context.
A total of 126 septic patients who visited the Emergency Department of Beijing Chao-Yang Hospital and 76 non-sepsis patients visiting the Physical Examination Center of Beijing Chao-Yang Hospital were enrolled. AGGF1 levels in plasma were detected by enzyme-linked immunosorbent assay. Spearman correlation analysis was used to determine correlations between plasma AGGF1 and Sequential Organ Failure Assessment (SOFA) score, Acute Pathology and Chronic Health Evaluation II (APACHE II) score, procalcitonin and lactate. We evaluated the classification significance of AGGF1 in sepsis using receiver operating characteristic (ROC) curves. We also assessed the predictive significance of AGGF1 for 28-day mortality in sepsis using ROC curves and Kaplan-Meier analyses.
Plasma AGGF1 levels were higher in sepsis patients than in non-sepsis patients (P < 0.001). Among sepsis patients, plasma AGGF1 levels were higher in non-survivors than in survivors (P < 0.001). Increased plasma AGGF1 levels were positively correlated with SOFA score, APACHE II score, procalcitonin and lactate. Plasma AGGF1 levels could distinguish sepsis patients from non-sepsis patients (area under the curve [AUC] = 0.777). AGGF1 had a higher predictive value than SOFA score, APACHE II score, lactate, procalcitonin, and white blood cell count for 28-day mortality in patients with sepsis (AUC = 0.876). Furthermore, Kaplan-Meier analysis indicated that lower plasma AGGF1 levels were associated with lower 28-day mortality compared with higher plasma AGGF1 levels (log rank P < 0.001).
AGGF1 is useful for the classification and evaluating prognosis of adult septic patients.
含G结构域和FHA结构域的血管生成因子1（AGGF1）是一种关键的血管生成因子，参与多种疾病及炎症反应的调节。然而，其在脓毒症中的作用尚不清楚。我们在临床环境中研究了AGGF1在成年脓毒症患者分类及预后评估中的作用。
纳入了126例就诊于北京朝阳医院急诊科的脓毒症患者以及76例就诊于北京朝阳医院体检中心的非脓毒症患者。采用酶联免疫吸附测定法检测血浆中AGGF1水平。采用Spearman相关性分析确定血浆AGGF1与序贯器官衰竭评估（SOFA）评分、急性生理与慢性健康状况评分系统II（APACHE II）评分、降钙素原及乳酸之间的相关性。我们使用受试者工作特征（ROC）曲线评估AGGF1在脓毒症分类中的意义。我们还使用ROC曲线和Kaplan-Meier分析评估AGGF1对脓毒症患者2周死亡率的预测意义。
脓毒症患者血浆AGGF1水平高于非脓毒症患者（P < 0.001）。在脓毒症患者中,非存活者的血浆AGGF1水平高于存活者（P < 0.001）。血浆AGGF1水平升高与SOFA评分、APACHE II评分、降钙素原及乳酸呈正相关。血浆AGGF1水平能够区分脓毒症患者与非脓毒症患者（曲线下面积[AUC]=0.777）。对于脓毒症患者的2周死亡率，AGGF1的预测价值高于SOFA评分APACHE II评分、乳酸、降钙素原及白细胞计数（AUC = 0.876）。此外,Kaplan-Meier分析表明，与血浆AGGF1水平较高者相比，血浆AGGF1水平较低者2周死亡率更低（对数秩检验P < 0.001）。
AGGF1有助于成年脓毒症患者的分类及预后评估。
