Prameswari Hawani Sasmaya, Dewi Triwedya Indra, Hasan Melawati, Martanto Erwan, Astuti Astri, Saboe Aninka, Cool Charlotte Johanna
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia.
Int J Gen Med. 2024 Mar 21;17:1073-1083. doi: 10.2147/IJGM.S447214. eCollection 2024.
Due to the rarity of peripartum cardiomyopathy (PPCM) globally, baseline characteristic data for PPCM patients are still scarce. Therefore, this study aims to determine the baseline characteristics and 6-month outcomes of PPCM patients in Indonesia.
From January 2014 to December 2021, all PPCM patients aged ≥18 years who were admitted to Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, participated in this single-center, prospective cohort study. All patients were re-evaluated within 6 months of PPCM diagnosis.
A total of 138 patients with PPCM were admitted to Dr. Hasan Sadikin General Hospital in Bandung. The mean age of all patients was 30.4 ± 6.4 years old. Approximately 60% patients were multipara and had preeclampsia. All guideline-directed medical therapy for heart failure was received by most patients, excluding mineralocorticoid receptor antagonists (25.2%) and bromocriptine (14.1%). The neonatal mortality rate was 5.1%. Among those who survived, 61.2% had normal weight, 31.8% had low birth weight, and 7% had very low birth weight. At the 6-month follow-up, 6.7% of the patients died, 63.3% recovered, and 1.9% were rehospitalized.
The present study found a high incidence of PPCM in Indonesia. Our patients frequently had preeclampsia, which contributed to the higher rate of miscarriage and low birth weight. Our liberal use of beta-blockers and ACEi/ARB may have contributed to the higher 6-month recovery rate than that in other countries.
由于全球围产期心肌病（PPCM）较为罕见，PPCM患者的基线特征数据仍然匮乏。因此，本研究旨在确定印度尼西亚PPCM患者的基线特征和6个月的预后情况。
2014年1月至2021年12月，所有年龄≥18岁、入住印度尼西亚万隆哈桑·萨迪金综合医院的PPCM患者参与了这项单中心前瞻性队列研究。所有患者在PPCM诊断后的6个月内进行了重新评估。
共有138例PPCM患者入住万隆哈桑·萨迪金综合医院。所有患者的平均年龄为30.4±6.4岁。约60%的患者为经产妇且患有先兆子痫。大多数患者接受了所有针对心力衰竭的指南指导药物治疗，但不包括盐皮质激素受体拮抗剂（25.2%）和溴隐亭（14.1%）。新生儿死亡率为5.1%。存活者中，61.2%体重正常，31.8%出生体重低，7%出生体重极低。在6个月的随访中，6.7%的患者死亡，63.3%康复，1.9%再次住院。
本研究发现印度尼西亚PPCM的发病率较高。我们的患者经常患有先兆子痫，这导致了较高的流产率和低出生体重率。我们对β受体阻滞剂和ACEi/ARB的大量使用可能是6个月康复率高于其他国家的原因。
