Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Deparment of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk Univiersity College of Medicine, Gyeongju, Korea.
J Korean Med Sci. 2024 Mar 25;39(11):e105. doi: 10.3346/jkms.2024.39.e105.
Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.
We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls.
Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54-1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81-2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17-2.92).
TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
结核病 (TB) 幸存者患慢性阻塞性肺疾病 (COPD) 的风险增加。本研究评估了与对照组相比，TB 幸存者发展 COPD 和 COPD 相关住院的风险。
我们使用 2010 年至 2017 年韩国国家健康保险服务数据库的数据，进行了一项基于人群的 TB 幸存者和年龄及性别匹配的 1:1 对照组的队列研究。我们比较了 TB 幸存者和对照组发展 COPD 和 COPD 相关住院的风险。
在研究对象中，9.6%发展为 COPD，2.8%经历了 COPD 相关住院。TB 幸存者的 COPD 发生率（36.7/1000 与 18.8/1000 人年， < 0.001）和 COPD 相关住院率（10.7/1000 与 4.3/1000 人年， < 0.001）明显更高。多变量 Cox 回归分析显示，TB 幸存者发展 COPD 的风险更高（调整后的风险比 [aHR]，1.63；95%置信区间 [CI]，1.54-1.73）和 COPD 相关住院（aHR，2.03；95% CI，1.81-2.27）。在发展为 COPD 的患者中，与非 TB COPD 患者相比，TB 后 COPD 患者的住院率更高（10.7/1000 与 4.9/1000 人年， < 0.001），显示出 COPD 相关住院的风险增加（aHR，1.84；95% CI，1.17-2.92）。
与对照组相比，TB 幸存者发生 COPD 和 COPD 相关住院的风险更高。这些结果表明，既往 TB 是 COPD 的一个重要病因，与 COPD 相关住院有关。
