Guseva O V, Zhukova N G
Siberian State Medical University, Tomsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(3):52-56. doi: 10.17116/jnevro202412403152.
To evaluate syndrome frailty by the Fried phenotype in patients with Parkinson's disease (PD).
Seventy-three patients over 65 years of age with Hoehn and Yahr stage 2-4 PD were tested for the presence of subjective criteria of the Fried phenotype of syndrome frailty: fatigue, difficulty in performing habitual activities, weight loss and objective criteria: grip strength and walking speed. The relationships of the objective criteria of Fried with indicators of age, sex, sports history, prescription of PD, the number of medications, blood pressure and MDS UPDRS part III scores, the severity of depression on the Beck scale and cognitive disorders on the MOCA were evaluated.
All patients complained of fatigue, difficulties in performing habitual activities. Four people noted a decrease in body weight of more than 5 kg per year. Objective criteria of Fried were absent in 38 (51%) patients, 23 (32%) people had one objective criterion: reduced walking speed (less than 0.8 m/s) or hand strength (less than 16 kg for women and 26 kg for men), in 12 (17%) people both objective criteria were reduced. The values of objective criteria of weakness were correlated with age, sex and MDS UPDRS part III total scores.
Frailty syndrome is difficult to diagnose in patients with PD due to the coincidence of complaints of the underlying disease and the syndrome. Objective criteria of the Fried phenotype suggest the presence of syndrome frailty in patients. The increase in the age of the patient, the female sex and the severity of PD are interrelated with the presence of objective criteria for the frailty of an elderly person.
通过Fried表型评估帕金森病（PD）患者的衰弱综合征。
对73例65岁以上、Hoehn - Yahr分期为2 - 4期的PD患者进行测试，以确定衰弱综合征Fried表型的主观标准：疲劳、进行日常活动困难、体重减轻，以及客观标准：握力和步行速度。评估Fried的客观标准与年龄、性别、运动史、PD处方、药物数量、血压、MDS UPDRS第三部分评分、Beck量表上的抑郁严重程度以及MOCA上的认知障碍指标之间的关系。
所有患者均主诉疲劳、进行日常活动困难。4人指出每年体重下降超过5kg。38例（51%）患者不存在Fried的客观标准，23例（32%）患者有一项客观标准：步行速度降低（低于0.8m/s）或手部力量降低（女性低于16kg，男性低于26kg），12例（17%）患者两项客观标准均降低。虚弱客观标准的值与年龄、性别和MDS UPDRS第三部分总分相关。
由于基础疾病和综合征的症状重叠，PD患者的衰弱综合征难以诊断。Fried表型的客观标准提示患者存在衰弱综合征。患者年龄增加、女性性别以及PD的严重程度与老年人衰弱的客观标准的存在相关。
