Ophthalmic Surg Lasers Imaging Retina. 2024 Jun;55(6):310-317. doi: 10.3928/23258160-20240130-01. Epub 2024 Mar 2.
Our objective was to evaluate retinal microvascular changes and visual outcomes following rhegmatogenous retinal detachment (RRD) repair using wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
The study included 116 eyes of 111 patients with macula-off ( = 68) or macula-on ( = 48) RRD treated with a single successful procedure, 79 fellow eyes, and 183 eyes of control patients imaged with WF SS-OCTA (3 ×3, 6 ×6, and 12 ×12 mm images). Mixed-effects multiple linear regression models were used for statistical analysis.
Vessel density (VD) and vessel skeletonized density (VSD) of the superficial capillary plexus (3 ×3 mm scans) and full-thickness retina (12 ×12 mm) were significantly reduced in RRD eyes compared to fellow and control eyes. Decreased VSD and VD in all layers (3 ×3 mm and 6 ×6 mm) were significantly associated with greater preoperative extent of retinal detachment ( < 0.05) and poorer postoperative best-corrected visual acuity (BCVA) in RRD eyes ( < 0.05). Macula-off status was associated with increased foveal avascular zone irregularity (12 ×12 mm, = 0.02).
Decreased VD on WF SS-OCTA is associated with poorer postoperative BCVA following RRD repair. .
本研究旨在使用宽视野扫频源光学相干断层扫描血管造影术（WF SS-OCTA）评估孔源性视网膜脱离（RRD）修复术后的视网膜微血管变化和视力结果。
该研究纳入了 111 例 116 只眼接受了单次成功手术治疗的黄斑脱离（=68 只眼）或黄斑未脱离（=48 只眼）RRD 患者，79 只对侧眼以及 183 只接受 WF SS-OCTA 检查的对照患者眼（3×3mm、6×6mm 和 12×12mm 图像）。采用混合效应多元线性回归模型进行统计学分析。
与对侧眼和对照组相比，RRD 眼的浅层毛细血管丛（3×3mm 扫描）和全视网膜（12×12mm）的血管密度（VD）和血管骨架密度（VSD）显著降低。所有层（3×3mm 和 6×6mm）的 VSD 和 VD 降低与术前视网膜脱离范围更大（<0.05）以及 RRD 眼术后最佳矫正视力（BCVA）更差（<0.05）显著相关。黄斑脱离状态与中心凹无血管区不规则性增加（12×12mm，=0.02）相关。
WF SS-OCTA 上的 VD 降低与 RRD 修复术后的术后 BCVA 较差相关。
