Department of Psychiatry, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650101, China.
Department of Gastroenterology, Nanchong Central Hospital, Nanchong, Sichuan Province, 637000, China.
Adv Biol (Weinh). 2024 May;8(5):e2400052. doi: 10.1002/adbi.202400052. Epub 2024 Mar 26.
This research conducted a two-sample univariate and multivariate Mendelian Randomization (MR) analysis to explore the causal link between different types of leisure sedentary behavior (LSB) and frailty. Independent instrumental variables significantly associated with sedentary behaviors (p < 5 × 10) are obtained from a genome-wide association study (GWAS) of 422,218 individuals, and Frailty Index (FI) are derived from the latest GWAS dataset of 175,226 individuals. MR analysis is conducted using inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode, supplemented by MRAPSS. Univariate MR revealed that sedentary behaviors such as watching television increased the risk of frailty (OR, 1.271; 95% CI: 1.202-1.345; p = 6.952 × 10), as sedentary driving behaviors are done (OR, 1.436; 95% CI: 1.026-2.011; p = 0.035). Further validation through APSS, taking into account cryptic relatedness, stratification, and sample overlap, maintained the association between television viewing and increased frailty risk (OR, 1.394; 95% CI: 1.266-1.534; p = 1.143 × 10), while the association with driving dissipated. In multivariate inverse variance weighted (IVW) analysis, after adjusting for C-reactive protein (CRP) levels, television Sedentary behavior (SB) inversely affected frailty (OR, 0.782; 95% CI: 0.724-0.845; p = 4.820 × 10). This study indicates that televisio SB significantly increases the risk of frailty, suggesting potential biological heterogeneity behind specific sedentary activities. This process may interact with inflammation, influencing the development of frailty.
本研究采用两样本单变量和多变量孟德尔随机化（MR）分析，探讨了不同类型的休闲久坐行为（LSB）与虚弱之间的因果关系。从 422218 人的全基因组关联研究（GWAS）中获得了与久坐行为显著相关的独立工具变量（p<5×10），并从最新的 175226 人的 GWAS 数据集中得出了虚弱指数（FI）。MR 分析采用逆方差加权、MR-Egger、加权中位数、简单模式和加权模式进行，辅以外推法（MRAPSS）。单变量 MR 显示，看电视等久坐行为会增加虚弱的风险（OR，1.271；95%CI：1.202-1.345；p=6.952×10），而久坐驾驶行为则会增加（OR，1.436；95%CI：1.026-2.011；p=0.035）。进一步通过 APSS 验证，考虑到隐匿性关联、分层和样本重叠，维持了看电视与增加虚弱风险之间的关联（OR，1.394；95%CI：1.266-1.534；p=1.143×10），而与驾驶的关联则消失了。在多变量逆方差加权（IVW）分析中，在校正 C 反应蛋白（CRP）水平后，电视久坐行为（SB）与虚弱呈负相关（OR，0.782；95%CI：0.724-0.845；p=4.820×10）。本研究表明，电视 SB 显著增加了虚弱的风险，表明特定久坐活动背后存在潜在的生物学异质性。这一过程可能与炎症相互作用，影响虚弱的发展。
