Zeng Wenming, Xia Jining, Zeng Qiming
Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang Province, China.
Department of Tuina, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan Province, China.
Postepy Dermatol Alergol. 2024 Feb;41(1):85-90. doi: 10.5114/ada.2024.135922. Epub 2024 Feb 28.
Inflammation is crucial in the pathogenesis of chronic spontaneous urticaria (CSU). Investigating the correlation between levels of serum inflammatory cytokines (SICs) and the severity of CSU is of great significance for understanding the disease mechanism and finding effective treatment strategies.
In this context, this work was developed.
This work involved a researchy group (Res group) of 114 patients with CSU and a control group (Ctrl group) of 100 healthy individuals. SICs including leukotriene B4 (LTB4), leukotriene C4 (LTC4), interleukin (IL) 4 (IL-4), IL-17, IL-31, and tumor necrosis factor-γ (TNF-γ), of patients in different groups were measured and compared. Furthermore, the correlations between each SIC and pruritus severity, duration of pruritus, urticaria activity, and quality of life (QOL) were compared among the patients in different groups.
The Res group exhibited higher levels of LTB4, LTC4, IL-4, IL-17, and IL-31 but lower levels of TNF-γ. Great differences ( < 0.05) were found in IL-4, IL-17, and IL-31 among the patients with different pruritus severity, and positive correlations were observed between IL-17 and IL-31 levels and urticaria activity in the patients ( < 0.05). Additionally, levels of IL-4 and IL-31 exhibited a positive association to QOL scores in the patients, with obvious differences ( < 0.05).
IL-4, IL-17, and IL-31 showed the strongest correlation with the severity of CSU, which may be attributed to their involvement in immune, inflammatory, and pruritic reactions, exacerbating the disease condition.
炎症在慢性自发性荨麻疹（CSU）的发病机制中至关重要。研究血清炎症细胞因子（SICs）水平与CSU严重程度之间的相关性，对于理解疾病机制和寻找有效的治疗策略具有重要意义。
在此背景下开展了本研究。
本研究纳入了114例CSU患者的研究组（Res组）和100名健康个体的对照组（Ctrl组）。检测并比较了不同组患者的SICs，包括白三烯B4（LTB4）、白三烯C4（LTC4）、白细胞介素（IL）-4（IL-4）、IL-17、IL-31和肿瘤坏死因子-γ（TNF-γ）。此外，还比较了不同组患者中各SIC与瘙痒严重程度、瘙痒持续时间、荨麻疹活动度及生活质量（QOL）之间的相关性。
Res组的LTB4、LTC4、IL-4、IL-17和IL-31水平较高，而TNF-γ水平较低。不同瘙痒严重程度的患者在IL-4、IL-17和IL-31方面存在显著差异（<0.05），且患者中IL-17和IL-31水平与荨麻疹活动度呈正相关（<0.05）。此外，患者中IL-4和IL-31水平与QOL评分呈正相关，差异明显（<0.05）。
IL-4、IL-17和IL-31与CSU严重程度的相关性最强，这可能归因于它们参与免疫、炎症和瘙痒反应，加重了病情。
