一种由多取代氨基咪唑并[5,1-]恶唑-6-鎓盐形成的侧向稠合N-杂环卡宾骨架。

Gillie Andrew D, Wakeling Matthew G, Greene Bethan L, Male Louise, Davies Paul W

School of Chemistry, University of Birmingham, Birmingham, B15 2TT, UK.

Beilstein J Org Chem. 2024 Mar 18;20:621-627. doi: 10.3762/bjoc.20.54. eCollection 2024.

A polysubstituted 3-aminoimidazo[5,1-]oxazol-6-ium framework has been accessed from a new nitrenoid reagent by a two-step ynamide annulation and imidazolium ring-formation sequence. Metalation with Au(I), Cu(I) and Ir(I) at the C2 position provides an L-shaped NHC ligand scaffold that has been validated in gold-catalysed alkyne hydration and arylative cyclisation reactions.

通过两步炔酰胺环化和咪唑鎓环形成序列，从一种新型氮烯试剂获得了一种多取代的3-氨基咪唑并[5,1 - ]恶唑-6-鎓骨架。在C2位置用Au(I)、Cu(I)和Ir(I)进行金属化，提供了一种L形NHC配体支架，该支架已在金催化的炔烃水合和芳基化环化反应中得到验证。