Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Electromagn Biol Med. 2024 Apr 2;43(1-2):125-134. doi: 10.1080/15368378.2024.2333802. Epub 2024 Mar 27.
The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results. Based on the mortality rates caused by cancer, the present study has considered six major organs affected by cancer, viz. lung, breast, stomach/gastric, liver, liver (with colon metastasis), and kidney for MWA analysis. The input power (100 W) and ablation times (4 minutes) with apt and inapt positioning of the trocar have been considered to compare the ablation volume of various cancerous tissues. The present study addresses one of the major problems clinicians face, i.e. the proper placement of the trocar due to poor imaging techniques and human error, resulting in incomplete tumor ablation and increased surgical procedures. The highest values of the ablation region have been observed for the liver, colon metastatic liver and breast cancerous tissues compared with other organs at the same operating conditions.
本研究分析了位于六个癌症高发器官的癌性肿瘤的微波消融,并评估了在微波消融过程中,将套管针适当地定位到组织中的输入功率和治疗时间参数的重要性。本研究考虑了一个三维两室肿瘤嵌入组织模型。使用内置生物传热、电磁波、固体和流体传热以及层流物理的基于有限元分析(FEA)的 COMSOL Multiphysics 软件来获得数值结果。基于癌症死亡率,本研究考虑了六个受癌症影响的主要器官,即肺、乳腺、胃/胃癌、肝、肝(伴有结肠转移)和肾,用于 MWA 分析。考虑了适当和不适当套管针定位的输入功率(100 W)和消融时间(4 分钟),以比较各种癌组织的消融体积。本研究解决了临床医生面临的一个主要问题,即由于成像技术不佳和人为错误导致的套管针的正确放置问题,这会导致肿瘤不完全消融和手术程序增加。在相同的操作条件下,与其他器官相比,肝脏、结肠转移性肝脏和乳腺癌组织的消融区域的最高值。