Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
College of Chemistry, Sichuan University, Chengdu, Sichuan, China.
Head Neck. 2024 May;46(5):1234-1247. doi: 10.1002/hed.27762. Epub 2024 Mar 27.
Laryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported over the preceding decade and all documented misdiagnosed LP cases. Furthermore, we systematically investigated the underlying causes of misdiagnosis and elucidated key points for effective differentiation. A retrospective analysis of 28 LP cases revealed a predominant occurrence in middle-aged women, with an average history of 25.1 months. Through an analysis of all misdiagnosed cases (n = 37), supraglottic LPs were frequently misidentified as laryngeal carcinomas and vascular tumors, while subglottic LPs were often misdiagnosed as thyroid cancers. And the occurrence of misdiagnosis resulted in delayed and inappropriate treatments, contributing to the deterioration of LP patients (14 cases, 37.8%). In conclusion, this review endeavored to heighten awareness of LPs, with the ultimate goal of advancing diagnostic precision and enhancing patient outcomes.
喉神经内分泌肿瘤（LP）是一种极为罕见的神经内分泌肿瘤，准确识别对于避免误诊至关重要。在本次综述中，我们呈现了两个典型的误诊 LP 病例，并对过去十年报道的 LP 病例和所有记录的误诊 LP 病例进行了回顾。此外，我们系统地研究了误诊的根本原因，并阐明了有效鉴别诊断的要点。对 28 例 LP 病例的回顾性分析显示，患者主要为中年女性，平均病史为 25.1 个月。通过对所有误诊病例（n=37）的分析，声门上型 LP 常被误诊为喉癌和血管肿瘤，而下型 LP 常被误诊为甲状腺癌。误诊导致了治疗的延误和不当，使 LP 患者的病情恶化（14 例，37.8%）。总之，本综述旨在提高对 LP 的认识，最终目标是提高诊断精度并改善患者的预后。
