Jensen Anders Bonde, Christiansen Peer, Bech Pernille, Zachariae Bobby
Danish Breast Cancer Group Centre for Late Effects, Aarhus Universitetshospital.
Kræftafdelingen, Aarhus Universitetshospital.
Ugeskr Laeger. 2024 Mar 18;186(12). doi: 10.61409/V02230091.
Improved survival after breast cancer treatment comes at a cost in the form of increased risk of late effects. A number of these are summarised in this review. The late effects can be divided in 1) late effects after locoregional treatment, e.g., lymphoedema, impaired shoulder movement, and pain; 2) consequences of systemic treatment, e.g. polyneuropathy, problems related to premature menopause, and increased risk of cardio-vascular disease; and 3) general late effects, commonly seen across all cancer types, including fatigue, insomnia, and cognitive impairment. There is a need for more knowledge about risk factors, prognoses, and the most effective treatments.
乳腺癌治疗后生存率的提高是以晚期效应风险增加为代价的。本综述总结了其中一些情况。晚期效应可分为:1)局部区域治疗后的晚期效应,如淋巴水肿、肩部活动受限和疼痛;2)全身治疗的后果,如多发性神经病、与过早绝经相关的问题以及心血管疾病风险增加;3)普遍的晚期效应,常见于所有癌症类型,包括疲劳、失眠和认知障碍。需要更多关于风险因素、预后和最有效治疗方法的知识。
Ugeskr Laeger. 2024-3-18
Health Technol Assess. 2022-2