Deutsch Andrew J
Department of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer ScienceWright State UniversityDaytonOhioUnited States.
J Neurophysiol. 2024 May 1;131(5):822-824. doi: 10.1152/jn.00482.2023. Epub 2024 Mar 27.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes motoneuron death. Alterations to motoneuron excitability in ALS are suspected to contribute to motoneuron degeneration. Therefore, mechanisms underlying changes in motoneuron excitability are being thoroughly investigated. A recent publication from Trajano et al. (Trajano GS, Orssatto LB, McCombe PA, Rivlin W, Tang L, Henderson RD. 601: 4723-4735, 2023) examined temporal changes to persistent inward currents (PICs) in ALS patients. They show that delta frequency (ΔF, an estimate of PICs) has opposite temporal trends in stronger and weaker muscles of ALS patients. This study is very important to aid in the understanding of disease mechanisms. This Neuro Forum article explores some important considerations for interpreting the results of this study, including treatment effects, potential sex differences, and a lack of comparison to healthy individuals.
肌萎缩侧索硬化症（ALS）是一种导致运动神经元死亡的致命性神经退行性疾病。ALS中运动神经元兴奋性的改变被怀疑与运动神经元变性有关。因此，正在深入研究运动神经元兴奋性变化的潜在机制。特拉贾诺等人最近发表的一篇文章（特拉贾诺GS、奥尔萨托LB、麦科姆PA、里夫林W、唐L、亨德森RD。601:4723 - 4735，2023）研究了ALS患者持续性内向电流（PICs）的时间变化。他们发现，δ频率（ΔF，PICs的一种估计值）在ALS患者较强和较弱的肌肉中呈现相反的时间趋势。这项研究对于帮助理解疾病机制非常重要。这篇神经论坛文章探讨了一些解释这项研究结果的重要注意事项，包括治疗效果、潜在的性别差异以及缺乏与健康个体的比较。
