Ramos-Velasco Beatriz, Naranjo Rocío, Izquierdo José M
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid (CSIC/UAM), C/Nicolás Cabrera 1, Cantoblanco, 28049 Madrid, Spain.
Biology (Basel). 2024 Mar 19;13(3):195. doi: 10.3390/biology13030195.
T-cell intracellular antigen 1 (TIA1) and TIA1-like/related protein (TIAL1/TIAR) are two members of the classical family of RNA binding proteins. Through their selective interactions with distinct RNAs and proteins, these multifunctional regulators are involved in chromatin remodeling, RNA splicing and processing and translation regulation, linking them to a wide range of diseases including neuronal disorders, cancer and other pathologies. From their discovery to the present day, many studies have focused on the behavior of these proteins in order to understand their impact on molecular and cellular processes and to understand their relationship to human pathologies. The volume of research on these proteins in various fields, including molecular biology, biochemistry, cell biology, immunology and cancer, has steadily increased, indicating a growing interest in these gene expression regulators among researchers. This information can be used to know the most productive institutions working in the field, understand the focus of research, identify key areas of involvement, delve deeper into their relationship and impact on different diseases, and to establish the level of study associated with them.
T 细胞细胞内抗原 1（TIA1）和 TIA1 样/相关蛋白（TIAL1/TIAR）是 RNA 结合蛋白经典家族的两个成员。通过与不同的 RNA 和蛋白质进行选择性相互作用，这些多功能调节因子参与染色质重塑、RNA 剪接与加工以及翻译调控，从而与包括神经紊乱、癌症和其他病症在内的多种疾病相关联。从它们被发现至今，许多研究都聚焦于这些蛋白质的行为，以便了解它们对分子和细胞过程的影响以及它们与人类病症的关系。在包括分子生物学、生物化学、细胞生物学、免疫学和癌症等各个领域，对这些蛋白质的研究数量稳步增加，这表明研究人员对这些基因表达调节因子的兴趣日益浓厚。这些信息可用于了解该领域中最具生产力的机构，理解研究重点，确定主要涉及领域，更深入地探究它们与不同疾病的关系及影响，并确定与之相关的研究水平。
