Wang Wei, He Qi-Tong, Chen Yin-Feng, Wang Bai-Hui, Xu Wen-Ying, Liu Qing-Lei, Liu Hui-Min
School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Engineering Research Center of Perfume & Aroma and Cosmetics, Ministry of Education, Shanghai 201418, China.
Gels. 2024 Mar 2;10(3):177. doi: 10.3390/gels10030177.
Ethylhexyl methoxycinnamate (EHMC) is frequently employed as a photoprotective agent in sunscreen formulations. EHMC has been found to potentially contribute to health complications as a result of its propensity to produce irritation and permeate the skin. A microgel carrier, consisting of poly(ethylene glycol dimethacrylate) (pEDGMA), was synthesized using interfacial polymerization with the aim of reducing the irritation and penetration of EHMC. The thermogravimetric analysis (TGA) indicated that the EHMC content accounted for 75.72% of the total composition. Additionally, the scanning electron microscopy (SEM) images depicted the microgel as exhibiting a spherical morphology. In this study, the loading of EHMC was demonstrated through FTIR and contact angle tests. The UV resistance, penetration, and skin irritation of the EHMC-pEDGMA microgel were additionally assessed. The investigation revealed that the novel sunscreen compound, characterized by limited dermal absorption, had no irritant effects and offered sufficient protection against ultraviolet radiation.
甲氧基肉桂酸乙基己酯（EHMC）常用于防晒配方中作为光保护剂。由于其易于产生刺激并渗透皮肤，已发现EHMC可能会导致健康问题。使用界面聚合法合成了一种由聚（乙二醇二甲基丙烯酸酯）（pEDGMA）组成的微凝胶载体，目的是减少EHMC的刺激和渗透。热重分析（TGA）表明，EHMC含量占总成分的75.72%。此外，扫描电子显微镜（SEM）图像显示微凝胶呈现球形形态。在本研究中，通过傅里叶变换红外光谱（FTIR）和接触角测试证明了EHMC的负载情况。此外，还评估了EHMC-pEDGMA微凝胶的抗紫外线能力、渗透性和皮肤刺激性。研究表明，这种新型防晒化合物具有有限的皮肤吸收特性，无刺激作用，并能提供足够的紫外线防护。
