Al-Nakhle Hakeemah H
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Monawarah 42353, Saudi Arabia.
Curr Issues Mol Biol. 2024 Feb 28;46(3):1832-1850. doi: 10.3390/cimb46030120.
Colorectal cancer (CRC) is a complex disease driven by intricate mechanisms, making it challenging to understand and manage. The miR-17-92 cluster has gained significant attention in CRC research due to its diverse functions and crucial role in various aspects of the disease. This cluster, consisting of multiple individual miRNAs, influences critical processes like tumor initiation, angiogenesis, metastasis, and the epithelial-mesenchymal transition (EMT). Beyond its roles in tumorigenesis and progression, miR-17-92's dysregulation in CRC has substantial implications for diagnosis, prognosis, and treatment, including chemotherapy responsiveness. It also shows promise as a diagnostic and prognostic biomarker, offering insights into treatment responses and disease progression. This review provides a comprehensive overview of recent advancements and the context-dependent role of the miR-17-92 cluster in colorectal cancer, drawing from the latest high-quality published data. It summarizes the established mechanisms governing miR-17-92 expression and the molecular pathways under its influence. Furthermore, it examines instances where it functions as an oncogene or a tumor suppressor, elucidating how cellular contexts dictate its biological effects. Ultimately, miR-17-92 holds promise as a biomarker for prognosis and therapy response, as well as a potential target for cancer prevention and therapeutic interventions. In essence, this review underscores the multifaceted nature of miR-17-92 in CRC research, offering promising avenues for enhancing the management of CRC patients.
结直肠癌（CRC）是一种由复杂机制驱动的复杂疾病，这使得理解和管理它具有挑战性。由于其多样的功能以及在该疾病各个方面的关键作用，miR-17-92簇在结直肠癌研究中受到了广泛关注。这个由多个个体miRNA组成的簇影响着肿瘤起始、血管生成、转移以及上皮-间质转化（EMT）等关键过程。除了在肿瘤发生和进展中的作用外，miR-17-92在结直肠癌中的失调对诊断、预后和治疗（包括化疗反应性）具有重要意义。它还显示出作为诊断和预后生物标志物的潜力，为治疗反应和疾病进展提供见解。本综述从最新的高质量已发表数据中全面概述了miR-17-92簇在结直肠癌中的最新进展以及其依赖于背景的作用。它总结了调控miR-17-92表达的既定机制以及受其影响的分子途径。此外，它还研究了miR-17-92作为癌基因或肿瘤抑制基因发挥作用的情况，阐明了细胞背景如何决定其生物学效应。最终，miR-17-92有望成为预后和治疗反应的生物标志物，以及癌症预防和治疗干预的潜在靶点。本质上，本综述强调了miR-17-92在结直肠癌研究中的多面性，为改善结直肠癌患者的管理提供了有前景的途径。
