Jia Dandan, Zhang Huijie, Liu Tiemin, Wang Ru
School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.
Metabolites. 2024 Feb 22;14(3):135. doi: 10.3390/metabo14030135.
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.
脂肪组织会随着衰老而发生变化，导致肥胖增加、炎症细胞浸润、血管生成减少、氧化应激增强以及代谢功能改变。规律运动已被认为是一种有力的干预措施，可对脂肪组织健康产生积极影响并减轻衰老的影响。然而，规律运动对衰老脂肪组织功能有益的分子机制仍知之甚少。通过规律运动释放的脂肪因子在减轻脂肪组织衰老、增强葡萄糖和脂质代谢、减少炎症和纤维化以及促进脂肪褐变和产热方面发挥潜在作用。本综述全面总结了规律运动在解决与年龄相关的脂肪组织功能下降方面的益处。利用这种方法的相关实例，我们探讨了基于这些分子机制设计治疗干预措施的可能性。
