破解 NLRP3 密码：炎症精准医学的先驱。
Cracking the NLRP3 code: Pioneering precision medicine for inflammation.
机构信息
Department of Innate Immunity, Institute of Immunology, University of Tübingen, Tübingen, Germany.
Clusters of Excellence EXC 2180 "iFIT-Image-Guided and Functionally Instructed Tumor Therapies" and EXC 2124 "CMFI-Controlling Microbes to Fight Infection," University of Tübingen , Tübingen, Germany.
出版信息
J Exp Med. 2024 May 6;221(5). doi: 10.1084/jem.20240221. Epub 2024 Mar 27.
Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome (CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome mutations, poses challenges. A novel classification approach may help inform therapeutic decisions and offer valuable insights into broader inflammatory conditions (Cosson et al. J. Exp. Med. 2024. https://doi.org/10.1084/jem.20231200).
精确诊断和有效治疗 Cryopyrin 相关周期性综合征（CAPS），一种与功能获得性 NLRP3 炎性体突变相关的炎症性疾病，具有挑战性。一种新的分类方法可能有助于为治疗决策提供信息，并为更广泛的炎症性疾病提供有价值的见解（Cosson 等人，《实验医学杂志》2024 年。https://doi.org/10.1084/jem.20231200）。
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