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未能通过在意大利心理健康服务机构中实施失眠心理干预来减少苯二氮䓬类药物处方。

Failure to reduce benzodiazepine prescriptions through the implementation of a psychological intervention for insomnia in an Italian mental health service.

机构信息

Laboratory of Evaluation of Quality of Care and Services, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Laboratory of Geriatric Epidemiology, Dipartimento di Salute Mentale, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

出版信息

Eur J Clin Pharmacol. 2024 Jul;80(7):1051-1060. doi: 10.1007/s00228-024-03677-7. Epub 2024 Mar 27.

Abstract

PURPOSE

Despite the evidence of higher effectiveness of psychological interventions for insomnia compared to pharmacological ones, drug prescriptions for insomnia remain frequent. This study has assessed patterns of prescriptions of BZDs for insomnia before and after the delivery of a training in psychological interventions to professionals working in the services of a Department of Mental Health in northern Italy.

METHODS

The intervention consisted in two training sessions about psychological interventions for insomnia delivered to professionals of the participating services. The prevalence of users with a prescription of BZDs for insomnia in an index period after the delivery of the training was compared to the prevalence in an index period before the training.

RESULTS

Among 727 people assessed for BZDs prescription at pre-intervention, 306 (42.1%, 95% CI 0.39-0.46) had a prescription, and 344 (49.2%, 95% CI 0.45-0.53) had a prescription among 699 people assessed at post-intervention, corresponding to a significant odds ratio of 1.33 to be prescribed with BZDs in the second index period compared to the first one. Psychological interventions were offered to a small group of patients.

CONCLUSION

Prescribing attitudes of BZDs for insomnia were not modified after the training and delivery of a psychological intervention in a mental healthcare outpatient setting. Prescribing habits should be addressed more directly in training, and professionals should be more aware of risks of BZDs assumption. The failure in changing drug prescriptions in this study should prompt more real-world studies of the application of evidence-based strategies, particularly in outpatient mental health settings.

摘要

目的

尽管有证据表明心理干预治疗失眠症比药物治疗更有效,但开处治疗失眠症的药物处方仍很常见。本研究评估了在向意大利北部某心理健康部门服务的专业人员提供心理干预培训前后,开处苯二氮䓬类药物(BZDs)治疗失眠症的模式。

方法

干预措施包括为参与服务的专业人员提供两次关于失眠症心理干预的培训课程。在培训后,评估了索引期内使用 BZD 治疗失眠症的患者比例,并与培训前的索引期内的患者比例进行了比较。

结果

在干预前评估 BZD 处方的 727 人中,有 306 人(42.1%,95%CI 0.39-0.46)有处方,在干预后评估的 699 人中,有 344 人(49.2%,95%CI 0.45-0.53)有处方,这意味着在第二个索引期内开处 BZD 的可能性比第一个索引期增加了 1.33 倍。心理干预仅提供给一小部分患者。

结论

在心理健康门诊环境中,提供心理干预培训后,BZD 治疗失眠症的处方态度并未改变。培训中应更直接地解决处方习惯问题,专业人员应更了解 BZD 使用的风险。本研究中药物处方未发生变化,这应促使更多基于证据的策略在现实世界中的应用研究,尤其是在心理健康门诊环境中。

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