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Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model.

作者信息

Lechauve Christophe, Keith Julia, Dudley Michael W, Fernandez Alfonso G, Khandros Eugene, Mayberry Kalin, Mayuranathan Thiyagaraj, Palmer Lance, Qiu Xiaohui, Sheppard Heather, Telange Rahul, Herz Hans-Martin, Weiss Mitchell J

机构信息

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.

Division of Hematology, The Children's Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

出版信息

Blood Adv. 2024 Dec 10;8(23):5988-5992. doi: 10.1182/bloodadvances.2024012681.

DOI:10.1182/bloodadvances.2024012681

PMID:38536944

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11629224/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a83/11629224/005e21a80b9e/BLOODA_ADV-2024-012681-gr1.jpg

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本文引用的文献

β-Thalassemias.

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The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia.

Sci Transl Med. 2019 Aug 21;11(506). doi: 10.1126/scitranslmed.aav4881.

Molecular Basis and Genetic Modifiers of Thalassemia.

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Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model.

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