Department of Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
Am Surg. 2024 Jul;90(7):1960-1962. doi: 10.1177/00031348241241695. Epub 2024 Mar 27.
Surgical site infections (SSIs) remain a significant cause of morbidity and mortality in patients undergoing traumatic exploratory laparotomy. The goal of this study was to compare antibiotic usage and subsequent outcomes in patients undergoing traumatic exploratory laparotomy. A retrospective chart analysis and a chi-square test of independence were performed to examine the relation between preoperative cefoxitin versus ceftriaxone and metronidazole and the rate of SSI development. 323 patients were analyzed, 111 patients receiving cefoxitin and 212 patients receiving ceftriaxone and metronidazole. The proportion of patients who developed SSI was 16.2% for the cefoxitin group and 9.9% for the ceftriaxone and metronidazole group, X2 (1, N = 323) = 2.7, = .098, thus displaying no statistical difference in the development of SSIs between patients in the cefoxitin group when compared to the ceftriaxone and metronidazole group.
术后手术部位感染（SSI）仍然是创伤性剖腹探查术患者发病率和死亡率的重要原因。本研究的目的是比较接受创伤性剖腹探查术的患者的抗生素使用情况和后续结果。通过回顾性图表分析和独立性卡方检验，研究了术前头孢西丁与头孢曲松和甲硝唑的关系与 SSI 发展的比率。对 323 名患者进行了分析，111 名患者接受头孢西丁治疗，212 名患者接受头孢曲松和甲硝唑治疗。头孢西丁组发生 SSI 的患者比例为 16.2%，头孢曲松和甲硝唑组为 9.9%，X2（1，N=323）=2.7，=0.098，因此头孢西丁组与头孢曲松和甲硝唑组相比，SSI 的发展没有统计学差异。
