Department of Neurology, Science and Technology Innovation Park of the Fourth Affiliated Hospital of Harbin Medical University, 150028 Harbin, Heilongjiang, China.
J Integr Neurosci. 2024 Mar 4;23(3):52. doi: 10.31083/j.jin2303052.
A hospital-based case-control study was carried out to elucidate the association of Matrix metalloproteinase-2 () gene candidate polymorphisms with the susceptibility to Alzheimer's disease (AD) in the Chinese Han population.
A total of 200 AD cases and an equal number of healthy controls were recruited to undergo genotyping of specific loci within the gene loci (, , ). Logistic regression analysis was applied to examine the association of the genotypes and alleles of gene polymorphisms with AD after adjusting clinical confounding factors.
Within AD group, a high proportion of genotype carriers were found, and the difference remained significant despite adjusting for other clinical indicators. Among individuals with the genotype and genotype, the onset age of AD occurred at a younger age. Early-onset AD risk in genotype carriers was 6.528 times higher than those in genotype carriers, and individuals with genotype faced a 4.048-fold increased risk compared to those with genotype.
gene and polymorphisms were closely associated with the onset age of AD. The presence of genotype emerged as a crucial predictor of AD risk.
本研究采用基于医院的病例对照研究，旨在阐明基质金属蛋白酶-2 () 基因候选多态性与中国汉族人群阿尔茨海默病（AD）易感性之间的关系。
共纳入 200 例 AD 病例和相同数量的健康对照者进行特定基因座内的基因多态性（、、）的基因分型。采用 logistic 回归分析调整临床混杂因素后，检验基因多态性的基因型和等位基因与 AD 的相关性。
在 AD 组中，发现大量携带 基因型的个体，且在调整其他临床指标后差异仍然显著。在 基因型和 基因型个体中，AD 的发病年龄较早。与携带 基因型的个体相比，携带 基因型的个体发生早发性 AD 的风险高 6.528 倍，携带 基因型的个体发生 AD 的风险比携带 基因型的个体高 4.048 倍。
基因和多态性与 AD 的发病年龄密切相关。携带 基因型是 AD 风险的重要预测因子。
