Mei W, Zhang Y P, Yang S J
Department of Pathology, The People's Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong 675000, China.
Department of Thoracic Surgery, The Fourth Affiliated Hospital of Dali University, Chuxiong 675000, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2024 Mar 20;42(3):232-240. doi: 10.3760/cma.j.cn121094-20221226-00604.
The occurrence of malignant mesothelioma is related to exposure of asbestos. And many researchers have conducted in-depth analysis of the molecular changes of mesothelioma, showed that its molecular characteristics were chromosome changes, including chromosome rearrangement, gene mutation and gene deletion. Recent studies have strengthened our understanding of molecular characterization of mesothelioma, such as targeted mutations of tumor suppressor genes, differential gene expression, changes of miRNA and signal pathways. It is of great significance for the early diagnosis, clinical treatment and prognosis of malignant mesothelioma to explore the pathogenesis and development of malignant mesothelioma. This article reviews the research progress on the pathogenesis and carcinogenesis-related molecules of malignant mesothelioma.
恶性间皮瘤的发生与接触石棉有关。许多研究人员对间皮瘤的分子变化进行了深入分析，结果表明其分子特征为染色体改变，包括染色体重排、基因突变和基因缺失。最近的研究加深了我们对间皮瘤分子特征的理解，如肿瘤抑制基因的靶向突变、基因表达差异、微小RNA和信号通路的变化。探索恶性间皮瘤的发病机制和发展过程对其早期诊断、临床治疗及预后具有重要意义。本文综述了恶性间皮瘤发病机制及致癌相关分子的研究进展。
